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Record W4367180229 · doi:10.21203/rs.3.rs-2846452/v1

Investigating the cecal microbiota of broilers raised in extensive and intensive production systems

2023· preprint· en· W4367180229 on OpenAlexafffund
Camila Schultz Marcolla, Tingting Ju, Hannah L. Lantz, Benjamin P. Willing

Bibliographic record

VenueResearch Square · 2023
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsUniversity of Alberta
FundersNatural Sciences and Engineering Research Council of CanadaCanada Research ChairsAlberta InnovatesAlberta Agriculture and Forestry
KeywordsBiologyBroilerFirmicutesBacteroidetesGut floraMicrobiomeBacteroidesMicrobiologyBacteria16S ribosomal RNAFood scienceImmunologyBioinformaticsGenetics

Abstract

fetched live from OpenAlex

Abstract Background Intensive broiler production practices are structured to prevent the introduction and spread of pathogens; however, they can potentially minimize the exposure of broilers to beneficial commensal bacteria. In this study, we used 16s rRNA amplicon sequencing to perform a large-scale characterization of the cecal microbiota of 35-day-old broilers from intensive production systems (IPS) and from extensive production systems (EPS), aiming to determine which microbes are normal inhabitants of the broiler ceca and which microbes might be missing from broilers in IPS. In addition, we generated a collection of bacterial isolates to be used as a resource to further explore the effects of selected isolates on bird physiology, and to elucidate the role of individual bacterial species within the cecal microbial community.Results Our results indicated major differences in the microbiota of broilers between systems: the microbiota of broilers from EPS was dominated by Bacteroidetes, whereas Firmicutes dominated the microbiota of broilers from IPS. A number of bacterial taxa ubiquitous in the EPS microbiota were shown to be infrequent or absent from the IPS microbiota, and the EPS microbiota presented higher phylogenetic diversity and greater predicted functional potential than that of broilers in IPS.Conclusions In the current study, we identified Olsenella, Alistipes, Bacteroides, Barnesiella, Parabacteroides, Megamonas, and Parasutterella as core bacteria within the broiler microbiota that seem to be depleted in broilers from IPS, which could be further investigated for their effects on bird physiology and potential application as next-generation probiotics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.097
GPT teacher head0.395
Teacher spread0.297 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2023
Admission routes2
Has abstractyes

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