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Record W4367552266 · doi:10.1093/ehjcvp/pvad032

Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease

2023· review· en· W4367552266 on OpenAlexafffund
Marco Valgimigli, Victor Aboyans, Dominick J. Angiolillo, Dan Atar, Davide Capodanno, Sigrun Halvorsen, Stefan James, Peter Jüni, Vijay Kunadian, Antonio Landi, Sergio Leonardi, Roxana Mehran, Gilles Montalescot, Eliano Pio Navarese, Josef Niebauer, Angelo Oliva, Raffaele Piccolo, Susanna Price, Robert F. Storey, Heinz Völler, Pascal Vranckx, Stephan Windecker, Keith A.A. Fox

Bibliographic record

VenueEuropean Heart Journal - Cardiovascular Pharmacotherapy · 2023
Typereview
Languageen
FieldMedicine
TopicAntiplatelet Therapy and Cardiovascular Diseases
Canadian institutionsUniversity of TorontoSt. Michael's Hospital
FundersAbbott VascularSt. Jude MedicalCytoSorbents EuropeIntas PharmaceuticalsIdorsia PharmaceuticalsTerumoSanofiAbiomedEisaiBiosensors International GroupMedicureInfraRedxMedicines CompanyCanada Excellence Research Chairs, Government of CanadaOsprey MedicalNovo NordiskDaiichi-SankyoRegeneron PharmaceuticalsBoston Scientific CorporationBristol-Myers SquibbEli Lilly and CompanyBiotronikAstraZenecaCSL BehringDaiichi Sankyo EuropeServierGilead SciencesBayer HealthCareCilagCardinal HealthEdwards LifesciencesAmgenPfizerUniversität Basel
KeywordsAntithromboticMedicineIntensive care medicineCoronary artery diseaseTerminologyRegimenFibrinolytic agentCardiologyInternal medicine

Abstract

fetched live from OpenAlex

Multiple guidelines and consensus papers have addressed the role of antithrombotic strategies in patients with established coronary artery disease (CAD). Since evidence and terminology continue to evolve, the authors undertook a consensus initiative to guide clinicians to select the optimal antithrombotic regimen for each patient. The aim of this document is to provide an update for clinicians on best antithrombotic strategies in patients with established CAD, classifying each treatment option in relation to the number of antithrombotic drugs irrespective of whether the traditional mechanism of action is expected to mainly inhibit platelets or coagulation cascade. With the aim to reach comprehensiveness of available evidence, we systematically reviewed and performed meta-analyses by means of both direct and indirect comparisons to inform the present consensus document.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.914
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.008
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.074
GPT teacher head0.340
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations62
Published2023
Admission routes2
Has abstractyes

Explore more

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