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Record W4367692342 · doi:10.1007/s12630-023-02431-4

A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline

2023· article· en· W4367692342 on OpenAlexafffundabout
Sam D. Shemie, Lindsay Wilson, Laura Hornby, John Basmaji, Andrew Baker, Cécile M. Bensimon, Jennifer A. Chandler, Michaël Chassé, Rosanne Dawson, Sonny Dhanani, Owen T. Mooney, Aimee Sarti, Christy Simpson, Jeanne Teitelbaum, Sylvia Torrance, J. Gordon Boyd, Joanne Brennan, Heather Brewster, Robert Carignan, Kirk J. Dawe, Christopher J. Doig, Kennedy Elliott-Pohl, Teneille Gofton, Michael Hartwick, Andrew Healey, Kimia Honarmand, Karen Hornby, George Isac, Aly Kanji, Joann Kawchuk, Jennifer A. Klowak, Andreas H. Kramer, Julie Kromm, Allana LeBlanc, Katarina Lee-Ameduri, Laurie A. Lee, Murdoch Leeies, Ariane Lewis, Alex Manara, Shauna Matheson, Nicole K. McKinnon, Nicholas Murphy, Joel Neves Briard, Thaddeus Mason Pope, Mypinder S. Sekhon, Jai Jai S. Shanker, Gurmeet Singh, Jeffrey M. Singh, Marat Slessarev, Karim Soliman, Stephanie Sutherland, Matthew J. Weiss, Randi Zlotnik Shaul, Lionel S. Zuckier, David J. Zorko, Bram Rochwerg

Bibliographic record

VenueCanadian Journal of Anesthesia/Journal canadien d anesthésie · 2023
Typearticle
Languageen
FieldMedicine
TopicCardiac Arrest and Resuscitation
Canadian institutionsCanadian Institutes of Health ResearchUniversité LavalLakeridge HealthCanadian VIGOUR CentreUniversity Health NetworkUniversity of AlbertaVancouver General HospitalSt. Peter's HospitalAlberta Children's HospitalVancouver Coastal HealthCanadian Nurses AssociationSAIT PolytechnicCanadian Cardiovascular SocietySaskatchewan Health AuthorityMcMaster UniversityUniversity of British ColumbiaWilliam Osler Health SystemUniversity of OttawaDalhousie UniversityLethbridge CollegeAlberta Health ServicesTrillium Therapeutics (Canada)University of TorontoMemorial University of NewfoundlandUniversity of CalgaryKingston General HospitalQueen's UniversityOttawa HospitalChildren's Hospital of Eastern OntarioUniversity of ManitobaUniversité de MontréalSt. Boniface HospitalCanadian Blood ServicesSt. Michael's HospitalUniversity of LethbridgeMcGill University Health CentreLondon Health Sciences CentreMcGill UniversitySt. John’s Health Sciences CentreHospital for Sick ChildrenNova Scotia Health AuthorityWestern UniversityDuPont (Canada)Canadian Medical Association
FundersHealth CanadaCanadian Medical AssociationCanadian Blood Services
KeywordsGuidelineClinical PracticeBrain functionIntensive care medicineMedicineFunction (biology)PsychologyNeurosciencePathologyFamily medicineBiology

Abstract

fetched live from OpenAlex

This 2023 Clinical Practice Guideline provides the biomedical definition of death based on permanent cessation of brain function that applies to all persons, as well as recommendations for death determination by circulatory criteria for potential organ donors and death determination by neurologic criteria for all mechanically ventilated patients regardless of organ donation potential. This Guideline is endorsed by the Canadian Critical Care Society, the Canadian Medical Association, the Canadian Association of Critical Care Nurses, Canadian Anesthesiologists' Society, the Canadian Neurological Sciences Federation (representing the Canadian Neurological Society, Canadian Neurosurgical Society, Canadian Society of Clinical Neurophysiologists, Canadian Association of Child Neurology, Canadian Society of Neuroradiology, and Canadian Stroke Consortium), Canadian Blood Services, the Canadian Donation and Transplantation Research Program, the Canadian Association of Emergency Physicians, the Nurse Practitioners Association of Canada, and the Canadian Cardiovascular Critical Care Society.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.556
Threshold uncertainty score0.994

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.042
GPT teacher head0.311
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations130
Published2023
Admission routes3
Has abstractyes

Explore more

Same venueCanadian Journal of Anesthesia/Journal canadien d anesthésieSame topicCardiac Arrest and ResuscitationFrench-language works237,207