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Record W4375853157 · doi:10.1021/cen-10115-acsnews

ACS honors insulin development

2023· article· en· W4375853157 on OpenAlexaboutno aff
ACS staff Sophie Rovner

Bibliographic record

VenueC&EN Global Enterprise · 2023
Typearticle
Languageen
FieldMedicine
TopicBiotechnology and Related Fields
Canadian institutionsnot available
Fundersnot available
KeywordsInsulinComputer scienceMedicineInternal medicine

Abstract

fetched live from OpenAlex

Diabetes used to be a death sentence, killing people by disrupting sugar metabolism. But in 1922, University of Toronto researchers and physicians successfully treated a boy with diabetes by injecting him with insulin extracted from animal pancreases. Physicians clamored for the new drug, so the university began collaborating with Eli Lilly and Company to satisfy the demand. The company refined and scaled up production techniques and delivered the world’s first commercial doses in 1923. The American Chemical Society honored Lilly’s role in these achievements with a National Historic Chemical Landmark designation ceremony in Indianapolis on March 27. Speakers at the event included ACS president-elect Mary Carroll and Leonard Glass, senior vice president of Lilly diabetes global medical affairs. “The global pandemic has demonstrated unambiguously that science matters,” Carroll said. “It has shown the critical importance of performing and publishing rigorous scientific work, educating students, and communicating science to elected officials

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.308
Threshold uncertainty score0.986

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.008
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0040.001
Scholarly communication0.0090.003
Open science0.0010.003
Research integrity0.0070.008
Insufficient payload (model declined to judge)0.3080.179

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.265
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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