Physical impairments, activity limitations, and participation restrictions of childhood acute lymphoblastic leukemia survivors: A PETALE cohort study
Bibliographic record
Abstract
Background: Long-term musculoskeletal complications represent a growing burden for survivors of childhood acute lymphoblastic leukemia (cALL). This study aimed to describe impairments, activity limitations, and participation restrictions of survivors of cALL at highest risk for late morbidity (PETALE cohort). Procedure: This retrospective study, using cross-sectional observational data from the PETALE cohort, included a subgroup of survivors who presented extreme phenotypes of late effects. Participants completed bilateral hip magnetic resonance imaging (MRI), assessment of maximal isometric muscle strength (MIMS), range of motion (ROM), Near Tandem Balance (NTB), 6-Minute Walk Test (6MWT), Five Time Sit-to-Stand Test (FTSST)), and quality of life (QOL). Descriptive statistics and regression analyses were performed. Results: 97 survivors were included in this study. The selected survivors (24.2 ± 6.7 years old) trended toward lower scores for most outcomes compared to available expected values referenced from a healthy population except for QOL. Thirteen participants (14.6%, 18 hips) had hip ON (53.8% male). Female survivors had hip ON with higher severity score (66.7% female vs. 22.2% male). Survivors with hip ON had reduced hip external rotation ROM compared to those without (p<0.05). Relationships were found between MIMS and ROM outcomes, and with 6MWT. Our multiple linear regression model explained 27.6% of the variance of the 6MWT. Conclusions: Although they reported QOL in the range of healthy peers, long-term cALL survivors at highest risk for late morbidity had clinically significant impairments and activity limitations. These data are in keeping with the frailty phenotype described in childhood cancer survivors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".