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Record W4375954606 · doi:10.1073/pnas.2218782120

Country-level gender inequality is associated with structural differences in the brains of women and men

2023· review· en· W4375954606 on OpenAlexaff
André Zugman, Luz María Alliende, Vicente Medel, Richard A. I. Bethlehem, Jakob Seidlitz, Grace Ringlein, Celso Arango, Aurina Arnatkevičiūtė, Laila Asmal, Mark A. Bellgrove, Vivek Benegal, Miquel Bernardo, Pablo Billeke, Jorge Bosch‐Bayard, Rodrigo A. Bressan, Geraldo F. Busatto, Mariana N. Castro, Tiffany Chaim-Avancini, Albert Compte, Monise Costanzi, Letícia Sanguinetti Czepielewski, Paola Dazzan, Camilo de la Fuente‐Sandoval, Marta Di Forti, Covadonga M. Díaz‐Caneja, Ana M. Díaz‐Zuluaga, Stefan S. du Plessis, Fábio Duran, Sol Fittipaldi, Alex Fornito, Nelson B. Freimer, Ary Gadelha, Clarissa Severino Gama, Ranjini Garani Ramesh, Clemente García‐Rizo, Cecilia González Campo, Alfonso González‐Valderrama, Salvador M. Guinjoan, Bharath Holla, Agustín Ibáñez, Daniza Ivanovic, Andrea Parolin Jackowski, Pablo León-Ortíz, Christine Löchner, Carlos López‐Jaramillo, Hilmar Luckhoff, Raffael Massuda, Philip McGuire, Jun Miyata, Romina Mizrahi, Robin Murray, Ayşegül Özerdem, Pedro Mário Pan, Mara Parellada, Lebogan Phahladira, Juan Pablo Ramírez-Mahaluf, Ramiro Reckziegel, Tiago Reis Marques, Francisco Reyes-Madrigal, Annerine Roos, Pedro Rosa‐Neto, Giovanni Abrahão Salum, Freda Scheffler, Günter Schumann, Maurício H. Serpa, Dan J. Stein, Ángeles Tepper, Jeggan Tiego, Tsukasa Ueno, Juan Undurraga, Eduardo A. Undurraga, Pedro A. Valdés‐Sosa, Isabel Valli, Mirta F. Villarreal, Toby Winton‐Brown, Nefize Yalın, Francisco Zamorano, Marcus V. Zanetti, Anderson M. Winkler, Daniel S. Pine, Sara Evans‐Lacko, Nicolás Crossley, Pratima Murthy, Amit Chakrabarti, Debasish Basu, B. N. Subodh, Lenin Singh, Roshan Lourembam Singh, Kartik Kalyanram, Kamakshi Kartik, Kalyanaraman Kumaran, Ghattu V. Krishnaveni, Rebecca Kuriyan, Sunita Simon Kurpad, Gareth J. Barker, Rose Dawn Bharath, Sylvane Desrivières, Meera Purushottam, Dimitri Papadopoulos Orfanos, Eesha Sharma, Matthew Hickman, Jon Heron, Mireille B. Toledano, Nilakshi Vaidya

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2023
Typereview
Languageen
FieldMedicine
TopicSex and Gender in Healthcare
Canadian institutionsCanadian Institute for Advanced ResearchDouglas Mental Health University InstituteMcGill UniversityMontreal Neurological Institute and Hospital
FundersNational Institutes of HealthMedical Research CouncilNational Institute for Health and Care Research
KeywordsInequalityGender inequalityDemographic economicsGender equalityPsychologyGender studiesSociologyEconomicsMathematics

Abstract

fetched live from OpenAlex

Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse socio-environmental experiences. Therefore, unequal exposure to harsher conditions for women compared to men in gender-unequal countries might be reflected in differences in their brain structure, and this could be the neural mechanism partly explaining women's worse outcomes in gender-unequal countries. We examined this through a random-effects meta-analysis on cortical thickness and surface area differences between adult healthy men and women, including a meta-regression in which country-level gender inequality acted as an explanatory variable for the observed differences. A total of 139 samples from 29 different countries, totaling 7,876 MRI scans, were included. Thickness of the right hemisphere, and particularly the right caudal anterior cingulate, right medial orbitofrontal, and left lateral occipital cortex, presented no differences or even thicker regional cortices in women compared to men in gender-equal countries, reversing to thinner cortices in countries with greater gender inequality. These results point to the potentially hazardous effect of gender inequality on women's brains and provide initial evidence for neuroscience-informed policies for gender equality.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.407
Threshold uncertainty score0.308

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.371
GPT teacher head0.439
Teacher spread0.068 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations60
Published2023
Admission routes1
Has abstractyes

Explore more

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