Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons
Bibliographic record
Abstract
Summary Central nervous system neurons have axons that vary over 100-fold in diameter. This diversity contributes to the regulation of myelination and conduction velocity along axons, which is critical for proper nervous system function. Despite this importance, technical challenges have limited our understanding of mechanisms controlling axon diameter growth, preventing systematic dissection of how manipulating diameter affects conduction along individual axons. Here, we establish zebrafish as system to investigate the regulation of axon diameter and axonal conduction in vivo . We identify a role for importin 13b specifically in axon diameter growth, that is independent of axonal length and overall cell size. Impairment of diameter growth along individual myelinated axons reduced conduction velocity in proportion to the diameter, but had no effect on the precision of action potential propagation or ability to fire at high frequencies. This work highlights an axon diameter-specific mechanism of growth that regulates conduction speeds along myelinated axons.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".