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Record W4378222446 · doi:10.26434/chemrxiv-2023-vcfwf

Autoxidation of Glycols Used in Inhalable DailyProducts: Implications to the Use of ArtificialFogs and E-cigarettes

2023· preprint· en· W4378222446 on OpenAlexafffund
Xinyang Guo, Ya-Chun Chan, Tania Gautam, Ran Zhao

Bibliographic record

VenueChemRxiv · 2023
Typepreprint
Languageen
FieldEnvironmental Science
TopicIndoor Air Quality and Microbial Exposure
Canadian institutionsUniversity of Alberta
FundersNatural Sciences and Engineering Research Council of CanadaCanada Foundation for InnovationUniversity of Alberta
KeywordsAutoxidationChemistryOrganic chemistryChromatographyEnvironmental chemistry

Abstract

fetched live from OpenAlex

The use of glycols is seen in various industries and occupations. In past decades, health implications from inhalable glycols have gained public attention. By impacting indoor air quality, inhalable glycols may cause adverse health effects, especially for workers in different occupations receiving frequent exposure. Our previous work highlighted the rapid accumulation of formaldehyde and glycolaldehyde in fog juice, thus proposing the occurrence of glycol autoxidation. However, the fundamentals of glycol autoxidation remained unclear and unexplored. Our goal is to investigate the autoxidation of common glycols during indoor storage. Carbonyls were quantified using liquid chromatography-mass spectrometry (LC-MS), and peroxides from autoxidation were monitored via iodometry and UV-Vis spectrometry. The impact of external factors was also investigated, such as the water mixing ratio, and antioxidants (Vitamin C). Via weekly monitoring, a rapid formation of aldehydes in many glycols was observed, such as E-cigarette juice and triethylene glycol (TEG). Occurrence of autoxidation was confirmed by the rise of the total peroxide concentration. Additionally, we highlighted the dependence of carbonyl formation rate on the TEG-water mixing ratio, demonstrating the complicated role water plays in glycol autoxidation. We have also tested the effectiveness of Vitamin C, with suggestions for minimizing the formation of toxic carbonyls in consumer products.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.092
GPT teacher head0.282
Teacher spread0.190 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes2
Has abstractyes

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