THE HIGH INCIDENCE ILLUSION: AKATHISIA WITH ARIPIPRAZOLE
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Bibliographic record
Abstract
Background: Clinicians have voiced concerns over the possibly high frequency of akathesia that occur with aripiprazole use, however, the existing literature is not consistent with these observations.
 Aim: To compare the frequency of akathesia occuring with aripiprazole and risperidone.
 Method: A total of 60 patients were included in the study. Patients fulfilling the inclusion criteria were then randomly assigned into 2 groups of 30 patients each. One group is given Aripiprazole (10 mg) and the other is prescribed Risperidone (2mg). Patients of both groups were re-called on the 7th day after the start of the medication and were screened and calibrated for Akathisia using the Barnes Akathisia Rating Scale (BARS) with a cut off value of 2 or more on global assessment indicating the presence of Akathisia. The patients not having akathesia of the 7th day were put in a sub-group and were re-assessed for presence of akathesia on the 21st day following start of antipsychotic.
 Results: The akathesia assessment done on the 7th day revealed the presence of akathesia in two (6.67%) patients getting Aripiprazole 10 mg. One patient (3.34%) in the group receiving Risperidone 2 mg presented with akathesia of the 7th post treatment day. Furthermore, no patients in either of the sub-groups had akathisia when assessed on 21st post treatment day. One way ANOVA analysis gave p=0.895.
 Conclusion: The frequency of akathesia occuring with Aripiprazole is comparable to that with Risperidone and is considered low.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it