Hypoglycemic effect of polysaccharides of Dendrobium officinale compound on type 2 diabetic mice
Bibliographic record
Abstract
This study investigated the hypoglycemic effect of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. Compared with the model group, the fasting blood glucose value of DOCP (800 mg/kg) at day 35 of the study significantly decreased (P < 0.05). Meanwhile, DOCP (800 mg/kg) significantly increased the serum insulin content and reduced the insulin resistance in type 2 diabetic mice. Furthermore, DOCP reduced the serum total cholesterol, triglyceride and LDL-C concentrations, increased the antioxidant capability, and improved liver and pancreas damage in type 2 diabetic mice. DOCP increased the diversity of intestinal flora composition, and the abundance of beneficial bacteria such as Lactobacillus and Bifidobacteriaceae. DOCP (800 mg/kg) induced up-regulation expression of genes such as Glut2, Gck, Pklr, Insr, Pdx-1 and Ins1, but elicited down-regulation of Caspase-3. These results indicate that DOCP achieves antidiabetic and hypolipidemic effects in type 2 diabetic mice.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".