Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- Meta-epidemiology (narrow), Research integrity
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Meta-analysisConsensus signal: Meta-analysis
- Genre
- Candidate signal: ReviewConsensus signal: Review
- Teacher disagreement score
- 0.222
- Threshold uncertainty score
- 1.000
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.004 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.295 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and implicated in extracellular matrix biology. One locus containing the tissue factor gene F3, which is involved in blood coagulation cascade initiation, appears to be specific for SCAD risk. Several associated variants have diametrically opposite associations with CAD, suggesting that shared biological processes contribute to both diseases, but through different mechanisms. We also infer a causal role for high blood pressure in SCAD. Our findings provide novel pathophysiological insights involving arterial integrity and tissue-mediated coagulation in SCAD and set the stage for future specific therapeutics and preventions.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Nature Genetics
- Topic
- Cardiovascular Issues in Pregnancy
- Field
- Medicine
- Canadian institutions
- Vancouver General HospitalUniversity of British Columbia
- Funders
- Common FundNational Institute of Diabetes and Digestive and Kidney DiseasesNational Cancer InstituteNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteEuropean Regional Development FundAstraZenecaNational Health and Medical Research CouncilNational Institutes of HealthU.S. Department of DefenseSociété Française de CardiologieMedical Research CouncilNSW Ministry of HealthFédération Française de CardiologieAgence Nationale de la RechercheNational Institute of General Medical SciencesCenter for Individualized Medicine, Mayo ClinicBritish Heart FoundationNational Institute for Health and Care ResearchNIH Office of the DirectorCardiac Society of Australia and New ZealandMichael Smith Health Research BCInstituto de Salud Carlos IIICentre Hospitalier Universitaire de Clermont-FerrandFONDATION ALZHEIMERA. Alfred Taubman Medical Research InstituteVictor Chang Cardiac Research InstituteUniversity of MichiganCanadian Institutes of Health ResearchAmerican Heart AssociationHeart and Stroke Foundation of Canada
- Keywords
- ScadBiologyCoronary artery diseaseGenome-wide association studyMyocardial infarctionGenetic associationBioinformaticsGeneGeneticsInternal medicineSingle-nucleotide polymorphismMedicineGenotype
- Has abstract in OpenAlex
- yes