The Impact Of Human Immunodeficiency Virus (HIV) Antiretroviral Drug Exposure In-Utero On Later Fertility
Bibliographic record
Abstract
Combination antiretroviral therapy (cART) reduces the risk of vertical human immunodeficiency virus (HIV) transmission. Two nucleoside reverse transcriptase inhibitors (NRTIs) are usually included in cART. The efficacy of cART has been extensively studied, but a significant knowledge gap exists concerning the effects of in-utero exposure on developing fetuses. In this project, we assessed the effects of HIV antiretrovirals on the reproductive health of offspring. Using Schizosaccharomyces pombe, we have shown that mutagenicity, but not toxicity, increases over time after dual-NRTI exposure. Our mouse pregnancy model suggests that in-utero cART exposure does not affect female germ cell development but alters the testes structure, thus adversely impacting male germ cell development. However, our study is limited in sample size and we aim to improve this by quantifying more gonad sections. Ultimately, we hope to provide more insight on the potential long-term fertility issues faced by children exposed inutero to antiretrovirals.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".