Synthesis and Biological Studies of Cationic Organoiron Star-Shaped Dendrimers Attached with Ketoprofen and Mefenamic Acid at the Peripheries
Bibliographic record
Abstract
Abstract The design of new star-shaped dendrimers with ketoprofen and mefenamic acid at the periphery was achieved using the divergent method. The use of cationic cyclopentadienyliron moieties coupled with the introduction of ketoprofen and mefenamic acid to the dendrimer allowed to produce dendrimeric materials that possess antimicrobial and anti-inflammatory activities. The dendrimers' compositions were analyzed through FT-IR, 1H-NMR, and 13C-NMR spectroscopic techniques. Furthermore, all synthesized dendrimers exhibited exceptional thermal stability within the 300 – 350oC range, with the cationic iron moieties breaking down at around 200oC. The surface morphology of the dendrimers was examined using Scanning Electron Micrographs (SEM) with no significant change between the three generations in the morphology. In addition, the electrochemical properties were also analyzed by Cyclic voltammetry (CV). The redox wave intensity and broadness showed changes as the dendrimer generation increased. These dendrimers were tested for their in vitro toxicities in mammalian cell lines, antimicrobial and anti-inflammatory activities and displayed positive results.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.003 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.002 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".