The Role of Mitogen Activated Protein Kinase Signalling On Cell Migration and Fluidity via Cytoskeletal Reorganization
Bibliographic record
Abstract
The abnormal regulation of the mitogen-activated protein kinase (MAPK) signalling pathway has been associated with the development of tumour cell invasion and metastasis through changes in the expression and activation of diverse cytoskeletal proteins (Qian et al., 2017). This research project intended to investigate the influence of MAPK signalling on cytoskeletal reorganization and its effects of cell fluidity on the migratory processes of MDA MB 231 human breast cancer cells. Selected (S3) cells isolated for enhanced motile characteristics were linked to increased downstream MAPK protein expressions and exhibited reduced actin and focal adhesion densities and lower actin anisotropy, observations that are correlated with softer cell structures. Cells treated with MEK inhibitors reversed these changes, demonstrating increased F-actin density and anisotropy as well as greater focal adhesion densities that were correlated with reduced cell speeds. These results reveal that MAPK signalling has a significant role in regulating cell biomechanics.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".