AB1204 THE COMPARISON OF THREE DIFFERENT MANAGEMENT STRATEGIES FOLLOWING PLATELET RICH PLASMA INJECTION IN PATIENTS WITH KNEE OA
Bibliographic record
Abstract
Background The main symptoms of patients with knee osteoarthritis (OA) are defined as pain, muscle weakness and functional impairments. Muscle strengthening exercises are recommended in core treatment of conservative management of knee OA [1]. Recently, intraarticular platelet-rich plasma (PRP) injection has gained much attention for the management of knee OA. A combination of different approaches is also recommended for achieving better symptomatic relief. Objectives The aim of the study was to compare the effect of PRP plus supervised exercise, PRP plus home exercise and only PRP in patients with knee OA. Methods Patients with knee OA aged 45-70 years old were included. The demographic characteristics of the patients were recorded, and they were randomly divided into three groups: PRP plus supervised exercise group (PRP+SEG); PRP plus home exercise group (PRP+HEG); PRP group. The pain was assessed with visual analogue scale (VAS); knee functions were assessed with Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and the stair test was assessed with a 10-step stair. The PRP+SEG performed the exercises under the supervision of a physiotherapist and PRP+HEG performed the same exercises at home. Both PRP+SEG and PRP+HEG performed a total of 6-week (3 times/week) strengthening exercises for knee and hip muscles. The PRP group received only PRP injection. All assessments were performed at 3rd day after PRP injection and at 6th week. Results A total of 41 female patients (mean age: 56.65±±6.64 years; mean BMI: 28.82±5.19 kg/m2) were randomized (PRP+SEG (n=15); PRP+HEG (n=12); and PRP (n=14)). There was no significant difference between three groups at baseline (p>0.05). There was significant difference in VAS (p=0.001); WOMAC Pain (p=0.003); WOMAC-Function (p=0.001) and WOMAC Total (p=0.001) scores between three groups at 6th week. The PRP+SEG had greater relief in pain both VAS and WOMAC Pain scores and greater improvement in WOMAC Function and WOMAC Total scores compared to PRP+HEG and PRP at 6th week. There was no significant improvement in stair test and WOMAC Stiffness scores for all groups at 6th week (p>0.05) (Table 1). Conclusion A combination of supervised exercise with PRP injection resulted in better symptomatic relief in patients with knee OA. Clinicians should consider the effectiveness of supervised strengthening exercises for providing better improvement in pain and knee function after PRP injection. Reference [1]Bannuru RR, Osani M, Vaysbrot E, Arden N, Bennell K, Bierma-Zeinstra S, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis and cartilage. 2019;27(11):1578-89. Acknowledgements: NIL. Disclosure of Interests None Declared.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".