Lenalidomide-Associated Progressive Multifocal Leukoencephalopathy
Bibliographic record
Abstract
A man in his 80s with IgG kappa and free light chain multiple myeloma was admitted to hospital with several weeks’ history of falls and cognitive decline. Magnetic resonance imaging of the brain demonstrated bilateral lesions in the corona radiata, centrum semiovale, and corpus callosum. The suspicion for progressive multifocal leukoencephalopathy was raised due to his ongoing use of lenalidomide for multiple myeloma. A diagnostic lumbar puncture was performed, and polymerase chain reaction testing of his cerebral spinal fluid was positive for John Cunningham Virus. The patient was diagnosed with progressive multifocal leukoencephalopathy, and lenalidomide was stopped in consultation with his hematologist. The patient died three weeks after the diagnosis was established. Physicians should consider the diagnosis of progressive multifocal leukoencephalopathy in patients presenting with rapid cognitive decline and chronic use of immunosuppressive medications such as lenalidomide.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".