Bibliographic record
Abstract
Molecular Assay for COVIDFigure: molecular assay, COVID, LumiraDx, SARS-CoV-2, Flu A/B RNA STAR, FDA, qSTAR technology, nucleic acid extraction, influenza A, influenza B, tourniquet, abdominal aortic, Junctional Tourniquet-Stabilized device, hemorrhages, pelvic bleeding, EMS, blood test, concussion, TBI blood test, i-STAT TBI Plasma test, brain injury, CT scan, biomarkersLumiraDx is planning to make its SARS-CoV-2 & Flu A/B RNA STAR Complete assay commercially available in the United States and United Kingdom. The assay received an Emergency Use Authorization from the U.S. Food and Drug Administration and validation for use by the UK Health Security Agency under the Coronavirus Test Device Approvals, according to a company news release. (Feb. 26, 2023; https://bit.ly/3lwMc3n.) The assay uses the qSTAR technology portfolio, which utilizes a single-step direct method for nucleic acid extraction and amplification on validated open RT-PCR instruments. This amplification technology identifies and differentiates those suspected of having a respiratory viral infection consistent with COVID. The assay can detect and differentiate between influenza A, influenza B, and SARS-CoV-2 infections within 20 minutes from a single sample. The assay has been available in the Europe Union since June 2022. Clearance for Tourniquet The U.S. Food and Drug Administration granted 510(k) clearance to Compression Works' Abdominal Aortic and Junctional Tourniquet-Stabilized (AAJT-S) device. The junctional tourniquet controls noncompressible hemorrhages and has multiuse capabilities including use in the axilla and groin to stop junctional hemorrhage, the abdomen for pelvic bleeding and bilateral lower leg injuries, and pelvic fracture stabilization. This device can be used by EMS to stabilize victims with broken pelvises and suspected bleeding until they can be transported to a surgical team. Compression Works recently presented the AAJT-S at the Western Trauma Association meeting in Alberta, Canada, for use in trauma environments where zone 3 resuscitative endothelial balloon occlusion of the aorta (REBOA) is currently used. The device has been used by the U.S. military and EMS since 2013, and clinical studies have shown its usefulness as an adjunct to REBOA, according to a news release from the company. (March 30, 2023; https://bit.ly/3oM2I1n.) Blood Test for Concussion Abbott received FDA clearance for a laboratory traumatic brain injury blood test. This is the first commercially available TBI blood test, according to a news release from the company. (March 7, 2023; https://bit.ly/3oNIZy0.) The approval comes after FDA clearance of the company's i-STAT TBI Plasma test, a rapid blood test for concussion used on their Alinity I laboratory instruments. A TBI blood test can now be run on the laboratory instrument for evaluating patients 18 and older presenting with suspected mild traumatic brain injury (Glasgow Coma Scale score 13-15) within 12 hours of injury to assist in determining the need for a CT scan. The results of a blood sample are available in 18 minutes. The blood test measures the complementary biomarkers ubiquitin C-terminal hydrolase L1 and glial fibrillary acidic protein in blood plasma and serum. MS. TALBOT is an editorial assistant for Emergency Medicine News. Share this article on Twitter and Facebook. Access the links in EMN by reading this on our website: www.EM-News.com. Comments? Write to us at [email protected].
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.009 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.004 | 0.003 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.007 | 0.007 |
| Open science | 0.003 | 0.004 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.655 | 0.715 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".