Influence of self-assembly on the reactive sulfhydryl and antioxidant activity of aggregation-prone ovalbumin-derived peptides
Why this work is in the frame
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Bibliographic record
Abstract
Ovalbumin-derived peptides IFYCPIAIM, NIFYCPIAIM and YCPIAIMSA, containing a common region YCPIAIM, were previously identified as aggregation-prone peptides with variable fibril formation. In this study, we elucidated self-assembly mechanisms of the peptides, by determining the influence of self-assembly on sulfhydryl group accessibility. The free sulfhydryl group content and antioxidant capacity results demonstrate that the peptides assemble into β-sheets, possibly involving hydrogen bonding with the sulfhydryl groups. NIFYCPIAIM, IFYCPIAIM and YCPIAIMSA, in decreasing order, had the largest particle size, thioflavin T fluorescence, reactive sulfhydryl group content, and antioxidant activities. This demonstrates that the reactive sulfhydryl group content, which is influenced by the cysteine residue position relative to the N-terminal of the peptide, is dependent on fibrillation. Rheological studies further demonstrated the non-Newtonian shear-thinning behavior of the peptides. The results provide valuable insight on peptide self-assembly, which is imperative for future design of bioactive hydrogels with promising biomechanical properties for biomaterial applications.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it