Bibliographic record
Abstract
Infiltrated macrophages and resident microglia play a central role in the pathology of demyelinating diseases such as multiple sclerosis (MS). They promote lesion development by stimulating neuroinflammation, demyelination, and neurodegeneration by releasing inflammatory and toxic mediators. However, phagocytes can also adopt a lesion-resolving phenotype that facilitates remyelination through the secretion of anti-inflammatory and neurotrophic factors, and by the clearance of myelin debris. Our findings show that the lipid load of macrophages and microglia is a major determinant of their reparative potential. Phagocytosis of myelin initially reduces the inflammatory activity of phagocytes. However, continuous accumulation of myelin-derived lipids eventually blunts their protective features, and induces an inflammatory transcriptional profile. We show that promoting lipid efflux from foamy phagocytes resolves inflammation and promotes remyelination. Hence, targeting lipid metabolism in macrophages and microglia provides a promising strategy to induce repair in the central nervous system.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.036 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".