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Record W4383563318 · doi:10.23977/medbm.2023.010105

Physiological Study of Microglial Cell Polarization

2023· article· en· W4383563318 on OpenAlexaff
Jiayue Sun

Bibliographic record

VenueMEDS Basic Medicine · 2023
Typearticle
Languageen
FieldMedicine
TopicIntracerebral and Subarachnoid Hemorrhage Research
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsMicrogliaPhagocytosisTLR4Cell biologyCellImmune systemMedicineChemistryImmunologyNeuroscienceBiologyInflammationBiochemistry

Abstract

fetched live from OpenAlex

Microglia play an important role in the course of ICH (Intracerebral Hemorr-Hage), and its activation degree, phenotypic polarization, hematoma clearance mechanism and its interaction with nerve cells are hot topics in ICH research at present. In this paper, ICH was taken as an example, and the research progress of microglia function changes after ICH was summarized, and the phenotypic transformation of microglia was summarized. The nitrite peroxide produced by M1 microglia in the immune reaction externalizes the phosphoacyl serine residues outside the nerve cells and sends out phagocytic signals, so that microglia can play the role of brain phagocytosis and cause nerve cell damage. The expression of pro-inflammatory microglia (M1 type) and repair microglia (M2 type) increased, and the microglia were mainly M1 type. In addition, the expression of M1 microglia in ICH 72 h group was lower than that in ICH 24 h group, while the expression of M2 microglia in ICH72 h group was higher than that in ICH 24 h group. Compared with Sham group, the increasing trend of M1 microglia expression after ICH is consistent with the increasing trend of TLR4/NF-κ B.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.051
GPT teacher head0.331
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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Same venueMEDS Basic MedicineSame topicIntracerebral and Subarachnoid Hemorrhage ResearchFrench-language works237,207