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Record W4383619609 · doi:10.1002/ntls.20230007

Exhaled aerosols and saliva droplets measured in time and 3D space: Quantification of pathogens flow rate applied to SARS‐CoV‐2

2023· article· en· W4383619609 on OpenAlexaff
Adrian Roth, Mehdi Stiti, David Frantz, Andrew Corber, Edouard Berrocal

Bibliographic record

VenueNatural Sciences · 2023
Typearticle
Languageen
FieldMedicine
TopicInfection Control and Ventilation
Canadian institutionsNational Research Council Canada
FundersLunds UniversitetCrafoordska StiftelsenVetenskapsrådetStiftelsen för Strategisk Forskning
KeywordsSalivaCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ChemistryVirologyBiologyMedicinePathology

Abstract

fetched live from OpenAlex

Abstract SARS‐CoV‐2 and its ever‐emerging variants are spread from host‐to‐host via expelled respiratory aerosols and saliva droplets. Knowing the number of virions which are exhaled by a person requires precise measurements of the size, count, velocity and trajectory of the virus‐laden particles that are ejected directly from the mouth. These measurements are achieved in 3D, at 15,000 images/s, and are applied when speaking, yelling and coughing. In this study, 33 events have been analysed by post‐processing ∼500,000 images. Using these data, the flow rates of SARS‐CoV‐2 virions have been evaluated. At high concentrations, 10 7 virions/mL, it is found that 136–231 virions are ejected during a single cough, where the virion flow rate peak is capable of reaching 32 virions within a millisecond. This peak can reach tens of virions/ms when yelling but reduced to only a few virions/ms when speaking. At medium concentrations, ∼10 5 virions/mL, those results are hundreds of times lower. The total number of virions that are ejected when yelling at 110 dB, instead of speaking at 85 dB, increases by two‐ to threefold. From the measured data analysed in this article, the flow rate of other diseases, such as influenza, tuberculosis or measles, can also be estimated. As these data are openly accessible, they can be used by modellers for the simulation of saliva droplet transport and evaporation, allowing to further advance our understanding of airborne pathogen transmission. Key points Advanced, optimized and combined laser‐based imaging techniques for temporally sizing and tracking respiratory droplets and aerosols. Understanding how pathogens are being ejected from the mouth when speaking, yelling and coughing. Quantifying and analysing the variation of SARS‐CoV‐2 flow rates emission during exhalation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.917
Threshold uncertainty score0.196

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.301
Teacher spread0.271 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2023
Admission routes1
Has abstractyes

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