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Record W4383684554 · doi:10.58931/cect.2022.1214

Drug-induced (toxic) glaucoma

2022· article· en· W4383684554 on OpenAlexaff
Dima Kalache

Bibliographic record

VenueCanadian Eye Care Today · 2022
Typearticle
Languageen
FieldMedicine
TopicGlaucoma and retinal disorders
Canadian institutionsMcGill UniversityBausch Health (Canada)University of Toronto
Fundersnot available
KeywordsGlaucomaMedicinePolypharmacyGlaucoma medicationDrugPopulationBlindnessOpen angle glaucomaOphthalmologyCataractsOptometryIntensive care medicinePharmacologyEnvironmental health

Abstract

fetched live from OpenAlex

Glaucoma is the leading cause of irreversible blindness in the world and the second most common cause of blindness overall. The prevalence of glaucoma is approximately 3% of the population worldwide. Due to the fact that increasing age is a risk factor for the development of glaucoma, an increase in life expectancy worldwide will be associated with a predicted increase in the prevalence of glaucoma. Similarly, advancements in medicine and an aging population have led to an increase in polypharmacy. Nearly two-thirds of all US adults aged 40–64 and 90% of individuals ≥ 65 years of age have been prescribed 5 or more medications at a time. Unfortunately, when assessing glaucoma patients, physicians may overlook systemic medications and focus solely on the topical medications. However, many systemic drugs have been shown to cause or worsen glaucoma. Therefore, the rise in polypharmacy and its effect on glaucoma must be better understood in order to decrease the worldwide glaucoma burden. 
 Drug-induced glaucoma, or toxic glaucoma, is a form of secondary glaucoma that can be distinguished by the mechanism causing the glaucoma: open angle or closed angle glaucoma. The overall incidence of drug-induced glaucoma is unknown.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.465
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.234
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2022
Admission routes1
Has abstractyes

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