Bibliographic record
Abstract
Overexpression of BCL-2 has been demonstrated in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) cells where it mediates tumor cell survival and has been associated with resistance to chemotherapeutics. Venetoclax is a selective and orally bioavailable small- molecule inhibitor of BCL-2, an anti-apoptotic protein. Based on evidence demonstrating improvement in progression-free survival (PFS) and overall survival (OS), it has been approved in Canada for various regimens in the treatment of CLL and AML (i.e., venetoclax monotherapy, venetoclax/obinutuzumab and venetoclax/rituximab for CLL and venetoclax/azacitidine for AML). Initiation of venetoclax can be complicated as it requires ramp-up dosing with bloodwork and hydration to reduce the risk for tumor lysis syndrome (TLS). This article will focus on providing guidance during the initiation of venetoclax, particularly in resource limited centres.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.016 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.004 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.003 | 0.007 |
| Insufficient payload (model declined to judge) | 0.012 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".