Contrast-agnostic deep learning–based registration pipeline: Validation in spinal cord multimodal MRI data
Bibliographic record
Abstract
Medical image registration can be challenging, in that optimal solutions depend on the application domain (unimodal, multimodal, intra-subject and inter-subject), anatomical sites (e.g., brain, spinal cord (SC) and lungs), dimensionality of the data (2D, 3D and 4D), deformation constraints (rigid, affine and nonlinear) and computational time. Solutions that could accommodate a large variety of applications while producing satisfactory results are needed. SynthMorph was recently introduced as an unsupervised deep learning–based registration method. A particularly interesting feature is that training is performed on synthetic data so that registration becomes agnostic to image contrast and anatomy. However, SynthMorph is particularly sensitive to the initial closeness of the images. In this work, we extend the SynthMorph method by developing a cascaded pipeline of two models that can accommodate large and fine deformations, respectively. We also validate this pipeline for the registration of intra-subject multimodal and inter-subject uni/multimodal MRI data of the SC. This task is known to be particularly difficult due to the vicinity of multiple tissue types whose morphometrics can vary substantially across subjects and contrasts. Evaluation of the method was conducted on a publicly available dataset (spine-generic, 267 subjects) and was compared with a state-of-the-art benchmark: Spinal Cord Toolbox and Advanced Normalization Tools. Results demonstrate better registration accuracy compared with the benchmark and about 24–30 times faster on CPUs depending on the image size. This proposed pipeline provides an easy-to-use, accurate and fast solution for multimodal 3D registration. The code and trained models are freely available at https://github.com/ivadomed/multimodal-registration.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.010 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".