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Record W4384466672 · doi:10.7759/cureus.41974

Left Ventricular Outflow Occlusion: An Alternative Approach to Late Selective Fetal Termination in Monochorionic Twin Gestations

2023· article· en· W4384466672 on OpenAlexaff
Richard Brown, Anne‐Maude Morency

Bibliographic record

VenueCureus · 2023
Typearticle
Languageen
FieldMedicine
TopicAssisted Reproductive Technology and Twin Pregnancy
Canadian institutionsMcGill University
Fundersnot available
KeywordsMedicineGestationAsystoleFetusCaesarian sectionMonochorionic twinsObstetricsPregnancyCardiology

Abstract

fetched live from OpenAlex

We report the case of a monochorionic twin gestation discordant for a mutation in the chromodomain-helicase-DNA-binding protein 7 (CHD7) gene and cerebral abnormalities consequent to an early devastating cerebrovascular event. The parents elected for selective termination given the poor prognosis for this fetus, but given socio-economic considerations wished to defer this procedure as late in gestation as possible, despite awareness of the risks and limitations of existing techniques at the end of pregnancy. A novel technique was used to achieve selective feticide in the late-preterm period. An endovascular balloon catheter was used to occlude the left ventricular outflow and coronary circulations resulting in fetal asystole while also arresting fetoplacental flow in this fetus, immediately prior to the delivery of the healthy fetus.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.376
Threshold uncertainty score0.556

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.306
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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