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Record W4384695466 · doi:10.32388/mlp1tn.3

Cryptic evidence on underreporting of mRNA vaccine-induced cardiomyositis in the elderly: a need to modify antihypertensive therapy

2023· preprint· en· W4384695466 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueQeios · 2023
Typepreprint
Languageen
FieldMedicine
TopicViral Infections and Immunology Research
Canadian institutionsQueen's University
FundersQueen's University
KeywordsVaccinationAsymptomaticMedicineMyocarditisBlood pressureInternal medicinePediatricsCardiologyImmunology

Abstract

fetched live from OpenAlex

BACKGROUND Cardiomyositis has been considered a rare complication of COVID-19 vaccination that primarily affects young people. However, recent studies indicate under-reporting of cases in the elderly. Furthermore, post-mortem studies of five cases (median age 58) that died suddenly within 7 days of vaccination, indicate an autoimmune element. Albeit an individual case history, the author’s unexpected personal evidence supports the latter studies. METHODS Readings of blood pressure (BP) and pulse were taken twice daily. FINDINGS Seven days after the fifth of a series of anti-COVID-19 vaccinations, a “stress test” (15 min jog) in an elderly subject exposed a cardiac problem – arrhythmia and a rapid fall of BP with slow recovery. The timing suggested myocarditis as a post-vaccination _early_ side-effect that usually targets those more likely to exercise (i.e., the young). Thus, it is usually cryptic in the elderly. In addition, retrospective studies of his own BP readings during the vaccination period (2021-2023) revealed the sudden emergence of transient, but prolonged, falls of BP _several weeks_ after each of his last four vaccinations. These hypotensive episodes were cryptic (asymptomatic) and likely not detected in shorter post-vaccination analyses. INTERPRETATION Short-term post-vaccination side effects are distinct from those occurring after some weeks. The first category includes systemic or localized inflammatory responses that, in the case of the heart, might either trigger arrythmia and acute functional impairment, or remain cryptic. Localized responses could initiate tissue damage, culminating weeks later in the second category – asymptomatic but measurable functional impairment. Continuing regular dosages of antihypertensive medication during this period would likely intensify the hypotension. That this did not occur in the author’s case is attributed to his two-decade-long practice of modulating dosage daily, based on BP readings. Failure to follow this protocol might explain some sudden home deaths. A parallel is drawn with his previous study that showed the need to modify antihypertensive therapy in response to external temperature changes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.829
Threshold uncertainty score0.676

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.235
GPT teacher head0.416
Teacher spread0.181 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it