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Record W4385442111 · doi:10.1001/jama.2023.9535

Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19

2023· letter· en· W4385442111 on OpenAlexfundno aff
Bruce L. Davidson, Marcel Levi

Bibliographic record

VenueJAMA · 2023
Typeletter
Languageen
FieldMedicine
TopicCOVID-19 Clinical Research Studies
Canadian institutionsnot available
FundersCanadian Institutes of Health ResearchLifeArcResearch ManitobaHeart and Stroke Foundation of CanadaBrigham and Women's HospitalNational Institutes of HealthCancerCare Manitoba Foundation
KeywordsMedicineOtorhinolaryngologyFamily medicineNeurologyMEDLINEPsychiatry

Abstract

fetched live from OpenAlex

statin treatment in the treat-to-target group.While the effect of statin treatment on reducing clinical events is not solely caused by suppression of low-density lipoprotein cholesterol (LDL-C) level, and the authors adjusted for confounders, genetic factors such as apolipoprotein E gene polymorphisms may contribute to coronary artery disease and type 2 diabetes.2,3 Individual variations in the response to statin treatment may be closely associated with genetic factors, and the recommendation of a treat-to-target LDL-C strategy for patients with cardiovascular disease should be made after understanding the magnitude of genetic contribution to the ability of LDL-C reduction and prevention of cardiovascular events.Additionally, this study included substantially more men (n = 3172) than women (n = 1228), and the authors did not comment on sex difference in this study.1 The majority of women in this study were likely postmenopausal, and dyslipidemia increases over a woman's life span, with adverse changes occurring around menopause.4

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.016
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.007
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.016
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.062
GPT teacher head0.429
Teacher spread0.367 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2023
Admission routes1
Has abstractyes

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