PB2268: PAX5 ABERRANT EXPRESSION INCORPORATED IN MIPI-SP RISK SCORING SYSTEM EXHIBITS ADDITIVE VALUE IN MANTLE CELL LYMPHOMA
Bibliographic record
Abstract
Topic: 18. Indolent and mantle-cell non-Hodgkin lymphoma - Clinical Background: Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin lymphoma with highly heterogeneous clinical courses. Paired-box 5 (PAX5), the regulator of B cell differentiation and growth, is abnormally expressed in several types of cancers. However, the explicit link between PAX5 alterations and prognosis of MCL patients still needs further investigation. Aims: This study aims to explore the role of PAX5 expression in MCL patients and establish a novel risk scoring system for clinical risk assessment in MCL. Methods: We comprehensively analyzed the clinical features and laboratory data of eighty-two MCL cases. Positive and negative PAX5 expression were distinguished by immunohistochemical staining. Kaplan-Meier and Cox regression were employed to investigate the effect of different factors on the prognosis of MCL patients. Furthermore, a novel risk score system was established based on multivariate Cox analysis and was evaluated through the area under the receiver operating characteristic (ROC) curve. Results: In MCL patients, PAX5 positivity was associated with shorter overall survival (OS; p=0.011) and was identified as an independent prognostic factor. Survival analysis of other clinical characteristics demonstrated that high-risk score (p=0.028), Mantle Cell Lymphoma International Prognostic Index (MIPI) score (p=0.006), high ECOG (≥2; p=0.019), splenomegaly (p=0.002) and high level of β2-MG (≥2.65 mg/L; p=0.002) were correlated with worse OS. Moreover, the elevated β2-MG (p=0.027) and advanced MIPI score (p=0.014) were related to positive PAX5 expression. In MCL patients with PAX5 positive expression, β2-MG (≥2.65 mg/L; p=0.042), splenomegaly (p=0.005), Ki67 positive rate (≥30%; p=0.047) and LDH (≥202 U/L; p=0.046) were correlated with inferior OS. The novel risk scoring system called MIPI-SP was established and exhibited a superior prognostic value for OS depending on an area under the ROC curve (AUC) of 0.770 (95% CI, 0.658-0.881) than MIPI score with an AUC of 0.698 (95% CI, 0.576-0.820). Summary/Conclusion: This study provides insight into the potential role of PAX5 in MCL, and the novel risk scoring system MIPI-SP optimizes the risk stratification and facilitates prognosis evaluation in MCL patients. Keywords: Immunohistochemistry, Mantle cell lymphoma
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".