Extracting Drug-Drug and Protein-Protein Interactions from Text using a Continuous Update of Tree-Transformers
Bibliographic record
Abstract
Understanding biological mechanisms requires determining mutual protein-protein interactions (PPI). Obtaining drug-drug interactions (DDI) from scientific articles provides important information about drugs. Extracting such medical entity interactions from biomedical articles is challenging due to complex sentence structures. To address this issue, our proposed model utilizes tree-transformers to generate the sentence representation first, and then a sentence-to-word update step to fine-tune the word embeddings which are again used by the tree-transformers to generate enriched sentence representations. Using the tree-transformers helps the model preserve syntactical information and provide semantic information. The fine-tuning provided by the continuous update step adds improved semantics to the representation of each sentence. Our model outperforms other prominent models with a significant performance boost on the five standard PPI corpora and a performance boost on the one benchmark DDI corpus that are used in our experiments.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".