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Record W4385896603 · doi:10.21203/rs.3.rs-3231589/v1

The relationship between chronic anemia caused by hematologic disease and cognitive impairment

2023· preprint· en· W4385896603 on OpenAlexaboutno aff
Liaoyang Xu, Hang Zhou, Xinyu Zhou, Ji-Feng Wei

Bibliographic record

VenueResearch Square · 2023
Typepreprint
Languageen
FieldMedicine
TopicAcute Myeloid Leukemia Research
Canadian institutionsnot available
FundersGovernment of Jiangsu Province
KeywordsAnemiaAnemia of chronic diseaseMedicineCognitionInternal medicinePediatricsIron-deficiency anemiaPsychiatry

Abstract

fetched live from OpenAlex

Abstract Patients with hematology disease ( such as aplastic anemia, primary myelofibrosis, and myelodysplastic syndrome) always in the condition of moderate and severe anemia for a long time. However, this chronic anemia condition impact on cognitive function was not well studied. We aim to explore the relationship between chronic anemia and cognitive function. We conducted a cross-sectional study. Collecting patients’ clinical dates and demographic characteristics from blood routine examination and self report. Objective cognition function was assessed by Chinese versions of Montreal Cognitive Assessment ( MoCA), total score of cognitive function and subscores of cognitive domains were calculated for each. Associations with chronic anemia and cognitive function were estimated using logistic regression. A total of 214 people including 70 chronic anemia and 144 non-anemia. Chronic anemia was independent factor for overall cognitive impairment, visual space and execution, attention, abstract and delayed recall (P < 0.05). The longer time of chronic anemia, the more possibility to have cognitive decline (P < 0.05). 36.5 months is a cutoff line for cognitive impairment among patients with chronic anemia. Chronic anemia can cause cognitive impairment; the longer time of chronic anemia, the easier to have cognitive decline.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.123
GPT teacher head0.434
Teacher spread0.311 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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