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Record W4385900010 · doi:10.1002/aro2.13

Multi‐trait genomic predictions using GBLUP and Bayesian mixture prior model in beef cattle

2023· article· en· W4385900010 on OpenAlexaff
Zezhao Wang, Haoran Ma, Hongwei Li, Lei Xu, Hongyan Li, Bo Zhu, El Hamidi Hay, Lingyang Xu, Junya Li

Bibliographic record

VenueAnimal Research and One Health · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic and phenotypic traits in livestock
Canadian institutionsUniversity of Alberta
FundersAgricultural Science and Technology Innovation ProgramUniversity of California, DavisCentral Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural SciencesChinese Academy of Tropical Agricultural SciencesChinese Academy of Agricultural SciencesNational Natural Science Foundation of China
KeywordsHeritabilityTraitBest linear unbiased predictionGenomic selectionGenetic correlationBayesian probabilityBeef cattleStatisticsSelection (genetic algorithm)BiologyAnimal scienceMathematicsGenetic variationGeneticsMachine learningSingle-nucleotide polymorphismComputer scienceGenotype

Abstract

fetched live from OpenAlex

Abstract Multiple trait genomic selection incorporating correlated traits can improve the predictive ability of low‐heritability traits. In this study, we evaluated genomic prediction accuracy using multi‐trait BayesCπ method (MT‐BayesCπ), which allows for a broader range of mixture priors for important traits in beef cattle. We compared the prediction performance of MT‐BayesCπ with single‐trait genomic best linear unbiased prediction (ST‐GBLUP), multi‐trait GBLUP (MT‐GBLUP), and single‐trait BayeCπ (ST‐BayesCπ) methods. We found that ribeye area (REA) and ribeye weight (REWT) showed high heritability, while slaughter weight (SWT) and carcass weight (CWT) displayed medium heritability, and slaughter rate (SR) and feedlot average daily gain (FDG) showed low heritability. Highly positive genetic correlations were observed between CWT and SWT (0.981) and SR and REWT (0.921). Notably, the MT‐BayesCπ method showed superior predictive abilities compared to other models. Using MT‐BayesCπ method, the accuracy increased from 0.272 to 0.694 for CWT compared to ST‐GBLUP and ST‐BayesCπ. MT‐GBLUP and ST‐BayesCπ showed similar prediction accuracies, while MT‐BayesCπ showed the least biased evaluations. Additionally, our results suggested that prediction accuracy of low‐heritability traits significantly increased when they were combined with traits with high genetic correlation in a multi‐trait prediction. Our study suggests that multi‐trait genomic predictions using GBLUP and Bayesian mixture prior models is feasible for genomic selection in beef cattle. Our findings indicate that MT‐BayesCπ outperforms other models (ST‐GBLUP, MT‐GBLUP and ST‐BayesCπ), especially for low‐heritability traits.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.920
Threshold uncertainty score0.344

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.093
GPT teacher head0.381
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2023
Admission routes1
Has abstractyes

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