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Record W4385989336 · doi:10.1016/j.annonc.2023.08.003

Neratinib + fulvestrant + trastuzumab for HR-positive, HER2-negative, HER2-mutant metastatic breast cancer: outcomes and biomarker analysis from the SUMMIT trial

2023· article· en· W4385989336 on OpenAlexafffund
Komal Jhaveri, L.D. Eli, Hans Wildiers, Sara A. Hurvitz, Ángel Guerrero‐Zotano, Nisha Unni, Adam Brufsky, H. Park, James Waisman, Eddy S. Yang, Iben Spanggaard, Sonya Reid, Mark E. Burkard, S Vinayak, Aleix Prat, Mónica Arnedos, François‐Clément Bidard, Sherene Loi, John Crown, Manali Bhave, Sarina A. Piha‐Paul, Jennifer M. Suga, Stephen Chia, Cristina Saura, José Á. García-Sáenz, Valentina Gambardella, Einav Nili Gal‐Yam, A. Raphael, Salomon M. Stemmer, X. Cynthia, Ariella B. Hanker, D. Ye, Jonathan W. Goldman, Ron Bose, Lanell M. Peterson, Joshua S. K. Bell, A. Lindsay Frazier, D. DiPrimeo, Alvin Wong, Carlos L. Arteaga, David B. Solit

Bibliographic record

VenueAnnals of Oncology · 2023
Typearticle
Languageen
FieldMedicine
TopicAdvanced Breast Cancer Therapies
Canadian institutionsBC Cancer Agency
FundersNational Cancer InstitutePrincipia BiopharmaImmunoMedicsSierra OncologyLoxo OncologyChugai PharmaceuticalAstraZenecaGenentechAmgenScience Foundation IrelandSeagenG1 TherapeuticsDaiichi-SankyoMacroGenicsSilverback TherapeuticsFibroGenPuma BiotechnologyNovartis Pharmaceuticals CorporationF-star TherapeuticsAminex TherapeuticsF. Hoffmann-La RocheGenomic HealthMenarini Silicon BiosystemsBeiGeneUniversity of Wisconsin Carbone Cancer CenterSun PharmaFive Prime TherapeuticsArray BioPharmaMerck KGaAMemorial Sloan-Kettering Cancer CenterNational Institutes of HealthNateraBioMarin PharmaceuticalAstellas PharmaEisaiDaiichi Sankyo EuropeUniversity of Wisconsin-MadisonNational Breast Cancer FoundationIncyteServierGilead SciencesExelixisJounce TherapeuticsBreast Cancer Research FoundationApollomicsSanofiGlaxoSmithKlineCelgeneBristol-Myers SquibbEli Lilly and CompanyPfizer
KeywordsFulvestrantNeratinibMedicineTrastuzumabMetastatic breast cancerInternal medicineOncologyResponse Evaluation Criteria in Solid TumorsBreast cancerCancerGastroenterologyProgressive diseaseChemotherapyTamoxifen

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.844
Threshold uncertainty score0.808

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.099
GPT teacher head0.420
Teacher spread0.322 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations61
Published2023
Admission routes2
Has abstractno

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