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Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial
David Conen, Michael Ke Wang, Ekaterine Popova, Matthew T.V. Chan, Giovanni Landoni, Juan P. Cata, Cara Reimer, Sean R. McLean, Sadeesh Srinathan, Juan Carlos Trujillo Reyes, Ascensión Martín Grande, Anna Gonzàlez Tallada, Daniel I. Sessler, Edith Fleischmann, Barbara Kabon, Luca Voltolini, Patrícia Cruz, Donna E. Maziak, Laura Gutiérrez-Soriano, Vikas Tandon, Elisabeth Martínez-Téllez, Juan Jose Guerra-Londoño, Deborah DuMerton, Randolph H.L. Wong, Anna McGuire, Biniam Kidane, Diego Parise Roux, Yaron Shargall, Jennifer R. Wells, Sandra Ofori, Jessica Vincent, Lizhen Xu, Zhuoru Li, John W. Eikelboom, Sanjit S. Jolly, Jeff S. Healey, P.J. Devereaux, William F. McIntyre, Mohammed Amir, Shrikant I. Bangdiwala, Matthias Bossard, Félix R. Montes, Denis Schmartz, Chew Yin Wang, Steffen Blum, Jesús Álvarez‐García, Giuliana Bianco, Hugh Traquair, Fernando Guerrero-Pinedo, Christopher Oleynick, Pascal Meyre, Francisco Javier Méndez, Hélène Chiarella-Redfern, Maura Marcucci, Francesco Donati, Aránzazu González Osuna, Fabrizio Minervini, Zoraida Moreno Weidmann, Gabriel Dion, Anna Ramos‐Pachón, Flávia K. Borges, Danielle de Sá Boasquevisque, Maria Giulia Mosconi, Pierre Amarenco, L. Brent Mitchell, George Wyse, Davy Cheng, Finlay A. McAlister, George A. Wells, Geethan Baskaran, Andrew Burns, Julia Gennaccaro, Rosemary Howe, Louise Mastrangelo, Shirley Pettit, Michelle Popovic, Subana Shahbaz, Makayla Tosh, Simona J. Zucchetto, Laura Heenan, Shun Fu Lee, Konrad Höetzenecker, Thomas Schweiger, Christian Reiterer, Oliver Zotti, Paul Bsuchner, Beatrix Hochreiter, Alexander Taschner, Nikolas Adamowitsch, Katharina Horvath, Nicole Hantáková, Javad Bidgoli, Isabelle Huybrechts, Serge Cappeliez, John Neary, Christian Finley, John Agzarian, Waël C. Hanna, Muammar Abdulrahman, Kelly Lawrence, Krysten Gregus, Faraaz Quraishi, Spencer Wikkerink, Christine Wallace, Merissa Prine, Emily Gregus, Jacqueline Hare, Kristen Lombardo, Behashta Fezia, Teresa Columbus, Jacob Rushton, Ken R. Reid, Joel L. Parlow, Wiley Chung, Maria Karizhenskaia, Aftab Ahmad Malik, Robert Tanzola, Andrew E. Giles, Jens Lohser, Shirley Geok‐lin Lim, Rebecca Grey, John Yee, Kyle Grant, Alex L. Lee, James J. Choi, Leith R. Dewar, Christopher Durkin, Travis Schisler, Patrick Hecht, Bevan Hughes, Richard Liu, Lawrence Tan, Stephen Gowing, Gordon Buduhan, Stephanie Enns, Emma Poole, Kristin M. Graham, Niina Dubik, Alex Chin, Andrew Seely, Sébastien Gilbert, Patrick J. Villeneuve, Sudhir Sundaresan, Molly Gingrich, A Fazekas, Richard Malthaner, Deb Lewis, Dalilah Fortin, Mehdi Qiabi, Rahul Nayak, Madelaine Plourde, Tusneem Haider, Rowan Murphy, Daniel Sellers, Laura Donahoe, Marco Lefebvre, L. Lanthier, Michael A. Ko, David N. Parente, Victoria Cheung, Colin Schieman, Amal Bessissow, Gavin M. Joynt, Carmen KM Lam, Rainbow WH Lau, Innes YP Wan, Malcolm J. Underwood, William Ka Kei Wu, Wai‐Tat Wong, Gordon YS Choi, Eva Lee, Ka Yan Hui, Beaker Fung, Fung Kei Ng, Kin Hoi Thung, Laura Carmenza Castañeda, Luis Jaime Téllez, Lina Marcela Ortiz-Ramirez, Martina Baiardo-Redaelli, Alessandro Belletti, Elisa Dieci, Fabrizio Monaco, Piergiorgio Muriana, Cristina Nakhnoukh, Pierluigi Novellis, Stefano Turi, Stefano Viscardi, Giulia Veronesi, Stefano Bongiolatti, Alberto Salvicchi, Lavinia Gatteschi, Rossella Indino, Simone Tombelli, Alice Ravasin, Ottavia Salimbene, Giulio Luca Rosboch, Eleonora Balzani, Edoardo Ceraolo, Luca Neitzert, Luca Brazzi, Francesco Londero, William Grossi, Domenico Massullo, Silvia Fiorelli, Stefano Margaritora, Shahrul Amry Hashim, Sivakumar Krishnasamy, Woan Shiang See, Mohammed Asghar Nawaz, Haris Bilal, Josep Belda Sanchís, Georgina Planas Cánovas, Alejandra Libreros Niño, Ana Parera Ruiz, Esther Cladellas Gutiérrez, Mauro Guarino, Marta Argilaga Nogues, Anna Rovira Juan, Melixa Medina‐Aedo, Ma Asunción Turró Castillejo, Josep Ma Gil Sanchez, Ibell Araúz-Sarmiento, Gracia Herranz Perez, S. Murillo, Álvaro García‐Osuna, Ainhoa Rodríguez‐Arias, Nuria Berga Garrote, Luis Gajate Martín, Angélica De Pablo Pajares, Angel Manuel Candela Toha, Nicolás Moreno‐Mata, Gema Muñoz Molina, Usue Caballero-Silva, Sara Fra‐Fernández, Cristina Cavestany García-Matres, L Simon, Cristina Montenegro, Sergio Pozo, Anna Gonzàlez-Tallada, Susana González Suarez, Montserrat Ribas Ball, Miriam De Nadal Clanchet, Javier Pérez Vélez, Guillermo Sánchez-Pedrosa, Patricia Duque, Guillermo González, Luis Huerta, Laura Rodríguez, Ignacio Garutti, Laura Ruiz-Villa, Maria del Mar Martí‐Ejarque, Mireia Gili-Bueno, Ricardo Matias Maddio Vieyra, Juan J. Fibla, Núria Durán, Alberto Rodríguez-Fuster, Silvia Bermejo-Martínez, Albert Carramiñana, Isabelle Opitz, Harry Etienne, Ravi Rajaram, German Corrales, Ara A. Vaporciyan, Reza J. Mehran, Boris Sepesi, Garrett L. Walsh, David C. Rice, Daniel S. Cukierman, Stephen G. Swisher, Bryan E. Marchant, Lynne Harris, Bruce Cusson, Scott Miller, Sabry Ayad, Jorge Araújo, Leonardo Marquez-Roa, Richard L. Hofstra, L. James Wudel, Steven C. Minear, Camila Teixeira, Mario Pimentel, Andrew M. Popoff, Kelly Marsack, Sarah Meehan, Tzonghuei H. Chen, Michael Essandoh, Jeremy S. Poppers
Bibliographic record
VenueThe Lancet · 2023
Typearticle
Languageen
FieldMedicine
TopicCardiac, Anesthesia and Surgical Outcomes
Canadian institutionsVancouver Coastal Health Research InstituteUniversity of OttawaOttawa HospitalUniversity of ManitobaVancouver General HospitalKingston Health Sciences CentreMcMaster UniversityQueen's UniversityImpactPopulation Health Research Institute
Fundersnot available
KeywordsMedicineAtrial fibrillationPerioperativePlaceboCardiac surgeryHazard ratioRandomized controlled trialInternal medicineSurgeryAnesthesiaConfidence interval
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.023
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.004 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.004 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.018
GPT teacher head0.311
Teacher spread0.293 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations75
Published2023
Admission routes1
Has abstractno