Synthesis and Identification of Thiazines-4-on Derived from Sulfamethoxazole, and Testing of Some of Their Antibacterial Properties
Bibliographic record
Abstract
The 2-Amino benzothiazol (A) was prepared by reacting Sulfamethoxazole with potassium thiocyanate in the presence of bromine as a catalyst.The 2-amino benzothiazol (A) was reacted with benzaldehyde derivatives in the presence of glacial acetic acid as a catalyst and ethanol as a solvent to produce the Schiff base derivatives (H1-H3).This method was also used to manufacture the Schiff base derivatives (H4-H6).Preparation of thiazines derived from Schiff base derivatives (H1-H3) with the appropriate solvent.The study evaluated the efficacy of several compounds against four bacterial strains, namely E. coli, Staphylococcus aureus, Streptococcus pyogenes, and Klebsiella pneumonia.The findings indicated that the tested compounds exhibited varying degrees of effectiveness against the bacteria at different concentrations (0.1, 1, and 10 mg/ml), with some demonstrating good to moderate activity.The standard antibiotic, Fluconazole, was also included in the experiment at a concentration of 5 mg/ml for comparison purp.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".