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Record W4386465397 · doi:10.1093/jcag/gwad008

The 2023 Impact of Inflammatory Bowel Disease in Canada: Direct Health System and Medication Costs

2023· review· en· W4386465397 on OpenAlexafffundabout
M Ellen Kuenzig, Stephanie Coward, Laura E. Targownik, Sanjay K. Murthy, Eric I. Benchimol, Joseph W. Windsor, Çharles N. Bernstein, Alain Bitton, Jennifer Jones, Kate Lee, Juan Nicolás Peña-Sánchez, Noelle Rohatinsky, Sara Ghandeharian, James Im, Rohit Jogendran, Saketh Meka, Jake Weinstein, Tyrel Jones May, Manisha Jogendran, Sahar Tabatabavakili, Elias Hazan, Malini Hu, Jessica Amankwah Osei, Rabia Khan, Grace Wang, Mira Browne, Tal Davis, Quinn Goddard, Julia Gorospe, Kate Latos, Kate Mason, Jack Kerr, Naji Balche, A. R. Sklar, Gilaad G. Kaplan

Bibliographic record

VenueJournal of the Canadian Association of Gastroenterology · 2023
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsQueen's UniversityUniversity of SaskatchewanMemorial University of NewfoundlandCrohn's and Colitis CanadaMcGill UniversityInstitute for Clinical Evaluative SciencesUniversity of OttawaMcGill University Health CentrePublic Health OntarioUniversity of ManitobaUniversity Health NetworkOttawa HospitalDalhousie UniversitySickKids FoundationUniversity of TorontoUniversity of CalgaryMount Sinai Hospital
FundersTakeda CanadaPfizer CanadaJanssen CanadaAmgen CanadaBristol-Myers Squibb CanadaGoddard Space Flight CenterSandoz CanadaEli Lilly CanadaCrohn's and Colitis CanadaPfizerHospital for Sick ChildrenMylanCanadian Association of GastroenterologyGilead SciencesDairy Farmers of OntarioTakeda FoundationUniversity of TorontoAbbVie CanadaAmgenEli Lilly and CompanyBristol-Myers Squibb
KeywordsMedicineInflammatory bowel diseaseHealth careEmergency departmentIndirect costsDiseasePopulationOutpatient clinicFamily medicineEmergency medicineEnvironmental healthPediatricsInternal medicine

Abstract

fetched live from OpenAlex

Healthcare utilization among people living with inflammatory bowel disease (IBD) in Canada has shifted from inpatient management to outpatient management; fewer people with IBD are admitted to hospitals or undergo surgery, but outpatient visits have become more frequent. Although the frequency of emergency department (ED) visits among adults and seniors with IBD decreased, the frequency of ED visits among children with IBD increased. Additionally, there is variation in the utilization of IBD health services within and between provinces and across ethnocultural and sociodemographic groups. For example, First Nations individuals with IBD are more likely to be hospitalized than the general IBD population. South Asian children with Crohn's disease are hospitalized more often than their Caucasian peers at diagnosis, but not during follow-up. Immigrants to Canada who develop IBD have higher health services utilization, but a lower risk of surgery compared to individuals born in Canada. The total direct healthcare costs of IBD, including the cost of hospitalizations, ED visits, outpatient visits, endoscopy, cross-sectional imaging, and medications are rising rapidly. The direct health system and medication costs of IBD in Canada are estimated to be $3.33 billion in 2023, potentially ranging from $2.19 billion to $4.47 billion. This is an increase from an estimated $1.28 billion in 2018, likely due to sharp increases in the use of biologic therapy over the past two decades. In 2017, 50% of total direct healthcare costs can be attributed to biologic therapies; the proportion of total direct healthcare costs attributed to biologic therapies today is likely even greater.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.567
Threshold uncertainty score0.997

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.257
Teacher spread0.249 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations20
Published2023
Admission routes3
Has abstractyes

Explore more

Same venueJournal of the Canadian Association of GastroenterologySame topicInflammatory Bowel DiseaseFrench-language works237,207