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Record W4386465662 · doi:10.1093/jcag/gwad004

The 2023 Impact of Inflammatory Bowel Disease in Canada: Epidemiology of IBD

2023· review· en· W4386465662 on OpenAlexafffundabout
Stephanie Coward, Eric I. Benchimol, M Ellen Kuenzig, Joseph W. Windsor, Çharles N. Bernstein, Alain Bitton, Jennifer Jones, Kate Lee, Sanjay K. Murthy, Laura E Targownik, Juan Nicolás Peña-Sánchez, Noelle Rohatinsky, Sara Ghandeharian, James Im, Tal Davis, Jake Weinstein, Quinn Goddard, Julia Gorospe, Jennifer L. Bennett, Léa Caplan, Maxime Bergevin, Xin Yang, Kate Mason, Rhonda Sanderson, Colten Brass, Gilaad G. Kaplan

Bibliographic record

VenueJournal of the Canadian Association of Gastroenterology · 2023
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsInstitut Universitaire de Gériatrie de MontréalUniversité de MontréalUniversity of SaskatchewanInstitute for Clinical Evaluative SciencesUniversity of OttawaMcGill University Health CentreOttawa HospitalUniversity of ManitobaMount Sinai HospitalUniversity of CalgaryDalhousie UniversityUniversity of TorontoSickKids FoundationCrohn's and Colitis CanadaPublic Health Ontario
FundersTakeda CanadaPfizer CanadaGoddard Space Flight CenterSandoz CanadaMerck CanadaEli Lilly CanadaCrohn's and Colitis CanadaBristol-Myers Squibb CanadaGilead SciencesJanssen CanadaAmgen CanadaAbbVie CanadaAmgenPfizerEli Lilly and CompanyBristol-Myers Squibb
KeywordsMedicineIncidence (geometry)Inflammatory bowel diseaseEpidemiologyUlcerative colitisDiseasePopulationCrohn's diseaseCohort studyCohortEnvironmental healthInternal medicineDemography

Abstract

fetched live from OpenAlex

Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis, is recognized across the world, though Canada has among the highest burdens of IBD in the world. The Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC) led a six-province study that demonstrated the compounding prevalence of IBD in Canada from 400 per 100,000 in 2002 to 636 per 100,000 in 2014. The prevalence in 2023 is estimated at 825 per 100,000, meaning that over 320,000 people in Canada are living with IBD. Prevalence is forecasted to rise by 2.44% per year such that 1.1% of the population, 470,000 Canadians, will live with IBD by 2035. The overall incidence of IBD in 2023 is 30 per 100,000 person-years, indicating that over 11,000 Canadians will be newly diagnosed with IBD in 2023. Incidence is forecasted to rise by 0.58% per year up to 32.1 per 100,000 by 2035. The rising incidence of IBD is propelled by pediatric-onset IBD, which is rising by 1.23% per year from 15.6 per 100,000 in 2023 to 18.0 per 100,000 in 2035. In contrast, incidence rates among adults and seniors are relatively stable. Understanding the determinates of IBD has expanded through prospective cohort studies such as the Crohn's and Colitis Canada Genetic, Environmental, Microbial (CCC-GEM) project. Consensus recommendations towards diet, lifestyle, behavioural and environmental modifications have been proposed by international organizations with the goal of optimizing disease control and ultimately preventing the development of IBD. Despite these efforts, Canadian healthcare systems will need to prepare for the rising number of people living with IBD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.654
Threshold uncertainty score0.987

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.279
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations64
Published2023
Admission routes3
Has abstractyes

Explore more

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