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Record W4386503265 · doi:10.54097/ehss.v20i.11497

A Review on Several Recent Studies on Alzheimer’s Disease

2023· review· en· W4386503265 on OpenAlexaff
Yuejin Qin

Bibliographic record

VenueJournal of Education Humanities and Social Sciences · 2023
Typereview
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsDiseaseNeuroscienceOptogeneticsAlzheimer's diseaseBiologyBioinformaticsMedicineComputational biologyPsychologyPathology

Abstract

fetched live from OpenAlex

The research on Alzheimer’s disease (AD) has progressed in recent years. The potential risk factors for AD are multifaceted, which makes the diagnosis and treatment of AD extremely challenging. With the development of bioinformation other manipulations in the micro level, more and more research studies have revealed different aspects of the disease. This study summarizes current results on the etiology of AD as well as treatments for AD and their effectiveness by reviewing empirical findings. In the genetic level, some genes have been examined on mice model by inhibition or optogenetic activation and revealed pathways in the formation of AD. Apart from genes, proteomic studies on certain proteins have also revealed some related changes triggered by blood proteins. Meanwhile, researchers have tested non-invasive treatments such as affecting the brainwave of mice. However, the results do not always change into clinical treatments. The present study emphasizes the necessity to integrate these pieces of study and form a more comprehensive understanding of AD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.012
Threshold uncertainty score0.039

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0050.005
Science and technology studies0.0000.000
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0120.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.511
GPT teacher head0.536
Teacher spread0.025 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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