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Record W4386503265 · doi:10.54097/ehss.v20i.11497

A Review on Several Recent Studies on Alzheimer’s Disease

2023· review· en· W4386503265 on OpenAlexaff
Yuejin Qin

Bibliographic record

VenueJournal of Education Humanities and Social Sciences · 2023
Typereview
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsDiseaseNeuroscienceOptogeneticsAlzheimer's diseaseBiologyBioinformaticsMedicineComputational biologyPsychologyPathology

Abstract

fetched live from OpenAlex

The research on Alzheimer’s disease (AD) has progressed in recent years. The potential risk factors for AD are multifaceted, which makes the diagnosis and treatment of AD extremely challenging. With the development of bioinformation other manipulations in the micro level, more and more research studies have revealed different aspects of the disease. This study summarizes current results on the etiology of AD as well as treatments for AD and their effectiveness by reviewing empirical findings. In the genetic level, some genes have been examined on mice model by inhibition or optogenetic activation and revealed pathways in the formation of AD. Apart from genes, proteomic studies on certain proteins have also revealed some related changes triggered by blood proteins. Meanwhile, researchers have tested non-invasive treatments such as affecting the brainwave of mice. However, the results do not always change into clinical treatments. The present study emphasizes the necessity to integrate these pieces of study and form a more comprehensive understanding of AD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.842
Threshold uncertainty score0.595

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.511
GPT teacher head0.536
Teacher spread0.025 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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