Bathymodiolamides C, D, and E, Necrosis Inducers from a Deep-Sea Hydrothermal Vent Invertebrate Mussel, Bathymodiolus azoricus
Bibliographic record
Abstract
Three ceramides with intriguing structural features, bathymodiolamides C (1), D (2), and E (3), were isolated from the deep-sea hydrothermal vent invertebrate mussel Bathymodiolus azoricus that inhabits vent environments along the Mid-Atlantic Ridge. The molecular structures of these compounds were elucidated using a combination of Nuclear Magnetic Resonance spectroscopy, mass spectrometry, and chemical degradation. Biological activities were assessed by Lactate Dehydrogenase assay for necrosis induction and the patented ApopScreen cell-based screen for apoptosis-induction and potential anticancer activity. This represents a second report of ceramide natural products from B. azoricus.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".