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Record W4386565810 · doi:10.1016/s2213-2600(23)00297-7

Advancing the pipeline of cystic fibrosis clinical trials: a new roadmap with a global trial network perspective

2023· review· en· W4386565810 on OpenAlexafffund
Nicole Mayer-Hamblett, John P. Clancy, Raksha Jain, Scott H. Donaldson, Isabelle Fajac, Christopher H. Goss, Deepika Polineni, Félix Ratjen, Bradley S. Quon, Edith T. Zemanick, Scott C. Bell, Jane C. Davies, Manu Jain, Michael W. Konstan, Natanya R. Kerper, Tré LaRosa, Marcus Mall, Edward F. McKone, Kelsie Pearson, Joseph M. Pilewski, Lynne M. Quittell, Jonathan H. Rayment, Steven M. Rowe, Jennifer L. Taylor‐Cousar, George Retsch‐Bogart, D.G. Downey

Bibliographic record

VenueThe Lancet Respiratory Medicine · 2023
Typereview
Languageen
FieldMedicine
TopicCystic Fibrosis Research Advances
Canadian institutionsUniversity of British ColumbiaSickKids FoundationHospital for Sick ChildrenUniversity of Toronto
FundersNational Heart, Lung, and Blood InstituteNIHR Imperial Biomedical Research CentreNational Center for Advancing Translational SciencesMedical Research CouncilBundesministerium für GesundheitCanadian Institutes of Health ResearchNational Institutes of HealthNational Health and Medical Research CouncilEngineering and Physical Sciences Research CouncilInstitut National de la Santé et de la Recherche MédicaleDeutsche ForschungsgemeinschaftBundesministerium für Bildung und ForschungInsmedCSL BehringNational Institute for Health and Care ResearchCystic Fibrosis TrustChiesi FarmaceuticiLifeArcVertex PharmaceuticalsChiesi USANational Institute of Diabetes and Digestive and Kidney DiseasesSanofiGilead SciencesGenentechCystic Fibrosis Foundation
KeywordsCystic fibrosisClinical trialMedicinePopulationCystic fibrosis transmembrane conductance regulatorDiseaseIntensive care medicineBioinformaticsPathologyInternal medicineBiologyEnvironmental health

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.071
metaresearch head score (Gemma)0.086
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.071
Threshold uncertainty score0.375

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0710.086
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0090.005
Bibliometrics0.0060.005
Science and technology studies0.0010.005
Scholarly communication0.0130.023
Open science0.0040.007
Research integrity0.0110.020
Insufficient payload (model declined to judge)0.0130.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.339
GPT teacher head0.547
Teacher spread0.208 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations33
Published2023
Admission routes2
Has abstractno

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