Abstract PO-027: Clinical and genetic associations of biological sex and survival in head and neck squamous cell carcinoma
Bibliographic record
Abstract
Abstract Approximately half of all head and neck squamous cell carcinoma (HNSCC) patients die within the five years of diagnosis despite treatment. Some studies have found that women with HNSCC have worse overall prognosis. To investigate the characteristics of HNSCC stratified by biological sex, we analyzed HNSCC samples within the Cancer Genome Atlas dataset from 382 male and 141 female patients. Here, tumors from female patients were more likely to be HPV negative and located in the oral cavity, along with a higher diagnosis age for this patient population. In the tumors of female patients, we also observed increased expression of genes belonged to immune pathways and higher overall immune infiltrate. Although immune infiltrate influences patient prognosis, it did not explain the biological sex disparity in our multivariable Cox proportional hazard model. Instead, across HNSCC, we found that survival differences attributed to biological sex were largely due to differences in diagnosis age and HPV status. However, this was not the case when solely looking at patients with HNSCC in the larynx. In laryngeal HNSCC, women have significantly worse outcome that cannot be attributed to HPV status or other clinical features. Of note, the association of biological sex with outcome in laryngeal HNSCC is also observed in other datasets. The molecular underpinnings of this disparity have not yet been identified, but preliminary analyses suggest different patterns of genomic alterations correlating with biological sex. Our study provides insight into factors that contribute to worse prognosis for females with HNSCC, particularly of the larynx. Citation Format: Alexandria Yao, Andrew Petti, Nadia Mezghani, Fatemeh Momen-Heravi, Alison M. Taylor. Clinical and genetic associations of biological sex and survival in head and neck squamous cell carcinoma [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Innovating through Basic, Clinical, and Translational Research; 2023 Jul 7-8; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2023;29(18_Suppl):Abstract nr PO-027.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".