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Record W4386853242 · doi:10.1149/ma2023-01532641mtgabs

Electrochemical Biosensors for Clinical Analysis

2023· article· en· W4386853242 on OpenAlexaff
Leyla Soleymani, Yingfu Li

Bibliographic record

VenueECS Meeting Abstracts · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAdvanced biosensing and bioanalysis techniques
Canadian institutionsMcMaster University
Fundersnot available
KeywordsAptamerBiosensorNucleic acidDNADeoxyribozymeNanotechnologyBarcodeComputational biologyMolecular biologyChemistryBiologyComputer scienceBiochemistryMaterials science

Abstract

fetched live from OpenAlex

In this talk, we will discuss the marriage of nucleic acids with electrochemical biosensors for the development of rapid clinical tests. These tests integrate both functional nucleic acids (aptamers and DNAzymes) and antibody/DNA complexes for developing barcode-based electrochemical biosensors. The barcode is a DNA strand modified with an electrochemical label that can be detected using an electrochemical chip. Following the presentation of different DNA barcoding methods, we will also present strategies for operating these biosensors in blood, saliva, and urine for direct analysis of clinical samples for the diagnosis of infectious diseases and cancer without the need for target enrichment methods such as growth cultures or nucleic acid amplification. These devices demonstrate the potential for rapid clinical testing at the point-of-need.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.019
Threshold uncertainty score0.063

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.002
Science and technology studies0.0010.001
Scholarly communication0.0030.002
Open science0.0020.002
Research integrity0.0040.005
Insufficient payload (model declined to judge)0.0190.020

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.351
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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