3D‐Printed Low‐Cost Artificial Corneal Perfusion Chamber for Investigating Corneal Physiology and Diseases in Different Animal Species
Bibliographic record
Abstract
Corneal blindness is the fourth‐most common form of blindness in the world. The only current therapy is a cornea transplant; however, only 1 out of 70 people would receive a corneal transplant. While cell models can be used to develop therapies for corneal diseases, they cannot recapitulate the complexity of the tissue, as displayed in animal models, which are expensive and complex to carry out. Thus, ex vivo models that can recapitulate the cornea structure are critical. Herein, a series of open‐access 3D‐printed corneal perfusion chambers that can closely recapitulate the native curvature of the cornea is presented, while also maintaining internal ocular pressure, for different animal species. These devices are made available open access to the scientific community, allow the study of corneal physiology, diseases, and to aid in future therapeutic discovery for cornea treatments.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".