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Record W4386928528 · doi:10.1016/s2468-1253(23)00314-x

Joint statement in support of hepatitis C human challenge studies

2023· letter· en· W4386928528 on OpenAlexaff
Harvey J. Alter, Eleanor Barnes, Mia J. Biondi, Andrea L. Cox, Jake D Eberts, Jordan J. Feld, T. Jake Liang, Josh Morrison, Charles M. Rice, Naglaa H. Shoukry, David L. Thomas, Jennifer van Gennip, Charles Weijer, Alessio Aghemo, Matthew J. Akiyama, Mohammad Ali, Ralf Bader, Justin R. Bailey, Yasemin Balaban, Sayantan Banerjee, Ralf Bartenschlager, Thomas F. Baumert, Marina Berenguer, Ajeet Singh Bhadoria, Paolo Bonanni, Alcino Eduardo Bonella, Philip Bruggmann, Julie Bruneau, Rowena A. Bull, Maia Butsashvili, Pedro Cahn, Arthur L. Caplan, Richard Yetter Chappell, Francis V. Chisari, Raymond T. Chung, Graham Cooke, Olav Dalgård, Doan Y Dao, Ara Darzi, Douglas T. Dieterich, John Dillon, Gregory J. Dore, Joseph Doyle, Heidi E. Drummer, Anna P. Durbin, Geoffrey Dusheiko, Jake D. Eberts, Nir Eyal, Kyle Ferguson, Robert Flisiak, Xavier Forns, Graham R. Foster, Steven K. H. Foung, Meital Gal-Tanamy, Ed Gane, Adam J. Gehring, Jacob George, Marc G. Ghany, Daniel T. Gilbert, Kimberly Glaze, Kenneth W. Goodman, Jason Grebely, Saeed Hamid, Daniel M. Haybron, Richard Holton, Louis J. Ignarro, Tamika Jackson, Dale Jamieson, Jody Jollimore, Andrew H. Karaba, Marina B. Klein, Georg M. Lauer, Mansun Law, Stanley M. Lemon, Lin Liu, Volker Lohmann, Lung‐Yi Mak, Rui Tato Marinho, Abigail A. Marsh, Lesley Miller, Joshua Morrison, Francesco Negro, Bao-Vuong Nguyen, Kimberly Page, Kerry Paterson, Alisa Pedrana, Thomas Pietschmann, Steven Pinker, Stanley A. Plotkin, Stuart C. Ray, Nancy Reau, William Remak, Ezequiel Ridruejo, Richard J. Roberts, Alvin E. Roth, Nadine Rouphael, Rogier W. Sanders, Russell Sandvold, Arthur Schafer, Janke Schinkel, Wai‐Kay Seto, Peter Singer, Sunil S. Solomon, Chris Somerville, Mark Sonderup, Mark Sulkowski, Kawsar R. Talaat, Larry S. Temkin, Norah A. Terrault, Chloe L. Thio, Alex J. Thompson, N. Tzarum, Marc van der Valk, Imam Waked, Alec Walen, Christopher M. Walker, Heiner Wedemeyer, Dan Wikler, Dominic Wilkinson, Heather Youngs, Man‐Fung Yuen, Barry Zack, Ekaterina Zinger

Bibliographic record

Venue˜The œLancet. Gastroenterology & hepatology · 2023
Typeletter
Languageen
FieldMedicine
TopicHepatitis C virus research
Canadian institutionsWestern UniversityUniversité de MontréalToronto General HospitalOffice of the Chief Medical ExaminerUniversity of TorontoYork University
FundersNational Institute of Allergy and Infectious DiseasesMedical Research CouncilNational Institute for Health and Care ResearchNational Institute on Drug AbuseWellcome Trust
KeywordsBioethicsStatement (logic)Public healthMedicineHuman healthPolitical scienceEngineering ethicsEnvironmental healthPathologyLawEngineering

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.015
metaresearch head score (Gemma)0.041
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.093
Threshold uncertainty score0.079

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0150.041
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.003
Bibliometrics0.0010.001
Science and technology studies0.0060.003
Scholarly communication0.0090.005
Open science0.0040.002
Research integrity0.0930.059
Insufficient payload (model declined to judge)0.0110.022

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.159
GPT teacher head0.392
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2023
Admission routes1
Has abstractno

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