Record W4386936303 · doi:10.1016/j.medj.2023.08.005

A multi-country analysis of COVID-19 hospitalizations by vaccination status

2023· article· en· W4386936303 on OpenAlexfundno aff

Bronner P. Gonçalves, Waasila Jassat, Joaquín Baruch, Madiha Hashmi, Amanda Rojek, Abhishek Dasgupta, Ignacio Martín‐Loeches, Luis Felipe Reyes, Chiara Piubelli, Barbara Wanjiru Citarella, Christiana Kartsonaki, Benjamin Lefèvre, José W. López, Miles Lunn, Moritz U. G. Kraemer, Sally Shrapnel, Peter Horby, Zeno Bisoffi, Piero Olliaro, Laura Merson, Sheryl Ann Abdukahil, Kamal Abu Jabal, Nashat Abu Salah, Eka Airlangga, Ali Ait Hssain, Chika Akwani, Eman Al Qasim, Angela Alberti, Osama Aldabbourosama, Marta Alessi, Beatrice Alex, Abdulrahman Al‐Fares, Jeffrey Aliudin, Mohammed Alkahlout, Lana Almasri, Yousef Al-Saba’a, Rita Vieira Alves, Joana Alves Cabrita, Maria João Amaral, Phoebe Ampaw, Aditya John Anchan, Andrea Angheben, Yaseen M. Arabi, Antonio Arcadipane, Patrick Archambault, Lukas Arenz, Rakesh C. Arora, Elizabeth A. Ashley, Anika Atique, Moad Atlowly, Benjamin Bach, J. Kenneth Baillie, J. Kevin Baird, Valeria Balan, Renata Barbalho, Nicholas Yuri Barbosa, William Barclay, Michaela Barnikel, Netta Beer, Husna Begum, David Bellemare, Anna Beltrame, Giulia Bertoli, Cláudia Bianco, Felwa Bin Humaid, Jonathan Bitton, Catherine Blier, Debby Bogaert, Diogo Borges, Dounia Bouhmani, Thipsavanh Bounphiengsy, Latsaniphone Bountthasavong, Bianca M. Boxma‐de Klerk, Filipa Brás Monteiro, Luca Brazzi, Nina Buchtele, Danilo Buonsenso, Aidan Burrell, Ingrid G. Bustos, Joana Melo Cabrita, Eder Cáceres, Rui Caetano Garcês, Josie Campisi, Cecilia Canepa, Janice Caoili, Chiara Simona Cardellino, Filipa Cardoso, Filipe S. Cardoso, Sofia Cardoso, Gayle Carney, François Martin Carrier, Gail Carson, Mariana Cascão, José Casimiro, Silvia Castañeda, Nidyanara Castanheira, Paolo Cattaneo, Roberta Figueiredo Cavalin, Alexandros Cavayas, Müge Çevik, Bounthavy Chaleunphon, Adrienne Y L Chan, Meera Chand, Anjellica Chen, Matthew Pellan Cheng, Danoy Chommanam, Yock Ping Chow, Nathaniel Christy, Rolando Claure‐Del Granado, Sara Clohisey, Cassidy Codan, Marie Connor, G Cooke, Mary Copland, Amanda Corley, Andrea Cortegiani, Gloria Crowl, Claudina Cruz, Marc Csete, Paula Custódio, Ana da Silva Filipe, Andrew Dagens, Peter Daley, Zaina Dalloul, Heidi J. Dalton, Jo Ann Dalton, Juliana Damas, Nick Daneman, Emmanuelle A. Dankwa, Jorge Dantas, Frédérick D’Aragon, Cristina De Rose, Thushan I. de Silva, William Dechert, Emmanuelle Denis, Yael Dishon, Annemarie B Docherty, Christl A. Donnelly, Chloe Donohue, Phouvieng Douangdala, James Joshua Douglas, Triona Downer, Mark Downing, Thomas M Drake, Murray Dryden, Audrey Dubot‐Pérès, Susanne Dudman, Jake Dunning, Mathilde Duplaix, Lucian A. Durham, Anne Margarita Dyrhol-Riise, Michael Edelstein, Martina Escher, Mariano Esperatti, Catarina Espírito Santo, Jo�ão Estêv�ão, Amna Faheem, Cameron J Fairfield, Pedro Faria, Nataly Farshait, Jorge Fernandes, Marília Andreia Fernandes, Joana Ferrão, Mário Ferraz, Bernardo Ferreira, Claudia Figueiredo-Mello, Tom Fletcher, Brigid C. Flynn, Patricia Fontela, Simon Forsyth, Giuseppe Foti, Robert Fowler, Diego Franch-Llasat, Christophe Fraser, John F. Fraser, Ana Freitas Ribeiro, Caren Friedrich, Nora Fuentes, G Argin, Linda Gail Skeie, Carrol Gamble, Julia Garcia-Diaz, Esteban García-Gallo, Aisling Gavin, Nuno Germano, Moji Ghadimi, Praveen Kumar Ghisulal, Marco Giani, Jess Gibson, Michelle Girvan, Geraldine Goco, Joan Gómez‐Junyent, Margarite Grable, Christopher Green, William Greenhalf, Fiona Griffiths, Heidi Gruner, Yusing Gu, Anne‐Marie Guerguerian, Daniela Guerreiro, Daniel A. Haber, Hannah Habraken, Wael Hafez, Matthew Hall, Sophie Halpin, Shaher Hamdan, Raph L Hamers, Summer Hamza, Hayley Hardwick, Alan Hartman, Lars Heggelund, Ross Hendry, Martina Hennessy, Liv Hesstvedt, Dawn Higgins, Rupert Higgins, Samuel Hinton, Antonia Ho, Jan Cato Holter, Juan Pablo Horcajada, Jimmy Ming-Yang Hsu, Abby Hurd, Samreen Ijaz, Carlos Cañada Illana, Hugo Inácio, Mariachiara Ippolito, Tiago Isidoro, Clare Jackson, Denise Jaworsky, Synne Jenum, Philippe Jouvet, Alina Kalicinska, Christopher Kandel, Kevin Katz, Aasmine Kaur, Seán Keating, Andrea Kelly, Sadie Kelly, Kalynn Kennon, Sommay Keomany, Imrana Khalid, Michelle E. Kho, Saye Khoo, Peter Kiiza, Beathe Kiland Granerud, Anders Benjamin Kildal, Paul Klenerman, Gry Kloumann Bekken, Stephen R Knight, Volkan Korten, Caroline Kosgei, Deepali Kumar, Demetrios J. Kutsogiannis, François Lamontagne, Marina Lanza, Andrew Law, Andy Law, Teresa Lawrence, James Lee, Jennifer Lee, Todd C. Lee, Gary Leeming, Andrew G. Letizia, Gianluigi Li Bassi, Janet Liang, Wei Shen Lim, Andreas Lind, Samantha Lissauer, Diogo Lopes, Sara Machado, Nimisha Abdul Majeed, Frank Manetta, Ceila María Sant’Ana Malaque, Catherine Marquis, Laura Marsh, Marshall John, Alejandro Martín‐Quirós, Ana Martins, Caroline Martins Rego, Gennaro Martucci, David M. Maslove, Christina Matthew, Mayfong Mayxay, Colin McArthur, Anne McCarthy, Rachael McConnochie, Sarah E. McDonald, Allison McGeer, Chris McKay, Kenneth A McLean, Kusum Menon, Alexander J. Mentzer, António Mesquita, Dan M. Meyer, Alison Meynert, Efstathia Mihelis, Agostinho Monteiro, Giorgia Montrucchio, Sarah Moore, Shona C. Moore, Lina Morales Cely, Lucía Moro, Ben Morton, Caroline Mudara, Mo’nes Muhaisen, Fredrik Müller, Karl Erik Müller, Laveena Munshi, Srinivas Murthy, Dana A. M. Mustafa, Dave Nagpal, Mangala Narasimhan, Prashant Nasa, Matthew Nelder, Emily Neumann, Pauline Yeung Ng, Alistair Nichol, Lisa Norman, Alessandra Notari, Mahdad Noursadeghi, Dwi Utomo Nusantara, Giovanna Occhipinti, Katie O’Hearn, Larissa Rosa de Oliveira, David S. Y. Ong, Wilna Oosthuyzen, Peter Openshaw, Massimo Palmarini, Giovanna Panarello, Prasan Kumar Panda, Rachael Parke, Patrícia Patrício, Lisa Patterson, Mical Paul, Jorge Paulos, William A. Paxton, Mare Pejkovska, Rui Pereira, Michele Petrovic, Frank Olav Pettersen, Scott Pharand, Ooyanong Phonemixay, Soulichanya Phoutthavong, Maria de Piero, Carlos Pimentel, Catarina Pires, Ayodhia Pitaloka, Riinu Pius, Sergio Poli, Georgios Pollakis, Andra-Maris Post, Diana Póvoas, Jeff Powis, Viladeth Praphasiri, Mark G. Pritchard, Bambang Pujo Semedi, Gregory Purcell, Luisa Quesada, Else Quist‐Paulsen, Aldo Rafael, Mutia Rahardjani, José C. Ramalho, Rajavardhan Rangappa, Indrek Rätsep, Brenda Reeve, Dag Henrik Reikvam, Hongru Ren, Oleksa Rewa, Antonia Ricchiuto, Asgar Rishu, María Angélica Rivera Núñez, Stephanie Roberts, David Robertson, Ferran Roche‐Campo, Paola Rodari, Bernhard Roessler, Andrea Rossanese, Matteo Rossetti, Clark D. Russell, Aleksander Rygh Holten, Isabela Saba, Musharaf Sadat, Valla Sahraei, Leonardo Salazar, Gabriele Sales, Emely Sanchez, Vanessa Sancho‐Shimizu, Gyan Sandhu, Oana Săndulescu, Marlene Santos, Shirley Sarfo-Mensah, Iam Claire E. Sarmiento, Egle Saviciute, Justin Schaffer, Michael Schwameis, Gary Schwartz, J. T. Scott, James Scott-Brown, Malcolm G. Semple, Tânia Sequeira, Ellen Shadowitz, Anuraj H. Shankar, Catherine A. Shaw, Victoria Shaw, Rajesh Mohan Shetty, Bountoy Sibounheuang, Louise Sigfrid, Piret Sillaots, Wai Ching Sin, Dario Sinatti, Mahendra Singh, Vegard Skogen, Sue Smith, Joshua Solomon, Tom Solomon, Rima Song, Elisabetta Spinuzza, Shiranee Sriskandan, Thomas Staudinger, Stephanie-Susanne Stecher, Trude Steinsvik, Birgitte Stiksrud, Adrian Streinu‐Cercel, David I. Stuart, Decy Subekti, Jacky Y. Suen, Asfia Sultana, Charlotte Summers, Atie Suwarti, Jaques Sztajnbok, Shirin Tabrizi, Sara Taleb, Richard S. Tedder, João Teixeira, Hubert Tessier-Grenier, Shaun Thompson, Emma C. Thomson, Mathew Thorpe, Ryan S. Thwaites, Kristian Tonby, Marta Sánchez de la Torre, Rosario María Torres Santos-Olmo, Alexis F. Turgeon, Lance Turtle, Anders Tveita, Paweł Twardowski, Roman Ullrich, Timothy M. Uyeki, Piero Valentini, Luís Val-Flores, Michael Varrone, José Ernesto Vidal, César Vieira, Joy Ann Villanueva, Judit Villar, Andrea Villoldo, Chiara Vitiello, Manivanh Vongsouvath, Marina Wainstein, Steve Webb, Jia Wei, Sanne Wesselius, Murray Wham, Nicole White, Sue Willems, Bailey Williams, Virginie Williams, Evert‐Jan Wils, Jessica Wittman, Stephanie T. Yerkovich, Touxiong Yiaye, Maram Zahran, Maria Zambon

Bibliographic record

VenueMed · 2023

Typearticle

Languageen

FieldMedicine

TopicSARS-CoV-2 and COVID-19 Research

Canadian institutionsnot available

FundersNaval Medical Research Unit—2Horizon 2020Australian Research CouncilCanadian Institutes of Health ResearchHorizon 2020 Framework ProgrammePrince Charles Hospital FoundationAll-India Institute of Medical SciencesBill and Melinda Gates FoundationMedizinische Universität WienPublic Health EnglandWellcome TrustUniversity College DublinForeign, Commonwealth and Development OfficeNational Institute for Health Research Health Protection Research UnitUniversity of OxfordNorges ForskningsrådMedical Research CouncilUniversity of LiverpoolGoogle.orgEuropean CommissionUniversität WienUniversity of QueenslandImperial College LondonInstitute of Cancer ResearchNational Institutes of HealthKementerian Kesihatan MalaysiaHealth Research BoardNational Institute for Health and Care ResearchMinistero della SaluteSunnybrook Research InstituteRockefeller FoundationLiverpool Experimental Cancer Medicine Centre

KeywordsCase fatality rateMedicineVaccinationContext (archaeology)Coronavirus disease 2019 (COVID-19)CommonwealthIntensive care unitPneumoniaFamily medicineDiseaseIntensive care medicinePediatricsEpidemiologyInternal medicineImmunologyInfectious disease (medical specialty)Political scienceGeography

DOI10.1016/j.medj.2023.08.005

Abstract

fetched live from OpenAlex

BACKGROUND: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. METHODS: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. FINDINGS: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. CONCLUSIONS: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. FUNDING: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002

metaresearch head score (Gemma)0.003

Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated

Candidate categoriesnone

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Observational · Consensus signal: Observational

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.009

Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

Category	Codex	Gemma
Metaresearch	0.002	0.003
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.001	0.002
Bibliometrics	0.002	0.002
Science and technology studies	0.000	0.000
Scholarly communication	0.001	0.001
Open science	0.001	0.001
Research integrity	0.000	0.001
Insufficient payload (model declined to judge)	0.002	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041

GPT teacher head0.392

Teacher spread0.351 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.

Study designObservational

Domainnot available

GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5

Published2023

Admission routes1

Has abstractyes

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