The Relationship Between Hemoglobin And VO2max: A Systematic Review And Meta-analysis
Bibliographic record
Abstract
PURPOSE: There is widespread agreement about the key role of hemoglobin for oxygen transport. Both observational and interventional studies have examined the relationship between hemoglobin levels and maximal oxygen uptake (V̇O2max) in humans. However, some uncertainty remains. Thus, we examined the relationship between hemoglobin levels (hemoglobin concentration and hemoglobin mass) and V̇O2max (absolute and relative V̇O2max) among both observational and interventional studies. METHODS: A systematic search was performed on December 6th, 2021. The study procedures and reporting of findings followed PRISMA guidelines. Article selection and data abstraction were performed in duplicate by two independent reviewers. Primary outcomes were hemoglobin levels and V̇O2max values (absolute and relative). For observational studies, meta-regression models were used to examine the relationship between hemoglobin levels and V̇O2max values. For interventional studies, meta-analysis models were used to determine the change in V̇O2max values (standard paired difference) associated with interventions designed to modify hemoglobin levels or V̇O2max. Meta-regression models were performed to determine the relationship between a change in hemoglobin levels and the change in V̇O2max values. All results are presented as the Mean Slope Coefficient [95% Confidence Interval]. RESULTS: For observational data (226 studies), there was a positive association between absolute V̇O2max and hemoglobin levels (hemoglobin concentration; 0.404 [0.298, 0.510], hemoglobin mass; 0.005 [0.003, 0.007], and hematocrit; 0.146 [0.091, 2.000], (P < 0.001 for all)). Subgroup analyses demonstrated no sex-related differences among these relationships. For interventional data (158 studies), there was a positive association between the change of absolute V̇O2max (standard paired difference) and the change in hemoglobin levels (hemoglobin concentration (P < 0.0001) and hemoglobin mass (P = 0.006)). CONCLUSIONS: These findings suggest that V̇O2max values are closely associated with hemoglobin levels among both observational and interventional studies. Although our findings suggest a lack of sex differences in these relationships, there were limited studies incorporating females or stratifying results by biological sex.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.016 | 0.041 |
| Meta-epidemiology (narrow) | 0.003 | 0.002 |
| Meta-epidemiology (broad) | 0.018 | 0.037 |
| Bibliometrics | 0.007 | 0.009 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.004 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".