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Record W4387267670 · doi:10.1021/acs.inorgchem.3c02719

A Synthetic, Structural, Spectroscopic, and Computational Study of Alkali Metal–Thioether, −Selenoether, and −Telluroether Interactions

2023· article· en· W4387267670 on OpenAlexafffund
Novan A. G. Gray, Ignacio Vargas‐Baca, David J. H. Emslie

Bibliographic record

VenueInorganic Chemistry · 2023
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicOrganoselenium and organotellurium chemistry
Canadian institutionsMcMaster University
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsChemistryThioetherDeprotonationLithium (medication)Alkali metalPotassiumNuclear magnetic resonance spectroscopyCrystallographyMetalCrystal structureStereochemistryQuenching (fluorescence)Medicinal chemistryOrganic chemistryIon

Abstract

fetched live from OpenAlex

The rigid thioether- and selenoether-containing pro-ligands, 4,5-bis(phenylsulfido)-2,7,9,9-tetramethylacridan (H[AS 2 Ph2 ] ( 1 )) and 4,5-bis(phenylselenido)-2,7,9,9-tetramethylacridan (H[ASe 2 Ph2 ] ( 2 )), were deprotonated with one equiv of n BuLi to afford dimeric lithium complexes [Li(AE 2 Ph2 )] 2 (E = S ( 3 ), Se ( 4 )) or with one equiv of KCH 2 Ph to afford the previously reported potassium complexes [K(AS 2 Ph2 )(dme)] x ( 5 ) and [K(ASe 2 Ph2 )(dme) 2 ] ( 6 ). Attempts to prepare a direct telluroether analogue of compounds 1 – 2 were unsuccessful. However, the bulky selenoether- and telluroether-containing pro-ligands 4,5-bis(2,4,6-triisopropylphenylselenido)-2,7,9,9-tetramethylacridan (H[ASe 2 Tripp2 ] ( 7 )) and 4,5-bis(2,4,6-triisopropylphenyltellurido)-2,7,9,9-tetramethylacridan (H[ATe 2 Tripp2 ] ( 8 )) were accessed via the reaction of 4,5-dibromo-2,7,9,9-tetramethylacridan with three equiv of n BuLi, followed by the addition of two equiv of the corresponding diaryl dichalcogenide and quenching with dilute HCl (aq) . The new selenoether- and telluroether-containing pro-ligands were subsequently deprotonated using KCH 2 Ph to afford [K(AE 2 Tripp2 )(dme) 2 ] (E = Se ( 9 ), Te ( 10 )). Compounds 1 – 10 were characterized by 1 H, 13 C{ 1 H}, 77 Se{ 1 H}, 125 Te{ 1 H}, and 7 Li NMR spectroscopy, where applicable, and single-crystal X-ray structures were obtained for all lithium and potassium complexes ( 3 – 6 and 9–10 ). DFT calculations were also performed to assess the nature of bonding between the hard group 1 cations and the soft chalcogenoethers.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.389
Teacher spread0.335 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2023
Admission routes2
Has abstractyes

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