NS-AUA 2023 Annual Meeting Abstracts – Infertility, Impotence, General Urology
Bibliographic record
Abstract
Introduction: Plaque excision and grafting is employed in severe Peyronie's disease, such as those with refractory disease, significant deformity, or plaque calcification.The primary objective of this study was to evaluate the amount of elastin and collagen in Peyronie's disease plaques.This study also sought to evaluate outcomes, including improvement in erectile dysfunction, improvement in curvature, and complications in subjects undergoing plaque excision.Methods: The institutional review board approved this study.Retrospective chart review evaluated subjects who underwent plaque excision for Peyronie's disease.Peyronie's plaques from our institutional biobank were stained using Verhoeff Van Gieson stain for collagen and elastin.Results: Between January 2000 and October 2022, seven subjects were identified, six of whom had undergone a plaque excision with Tutoplast ® grafting, two of whom had plication, and one of whom had an unknown procedure.Median age was 54 years.Maximal angle of curvature was a median 70 degrees (range 40-90) and two had calcified plaques.Five subjects had erectile dysfunction.All had subjective curvature improvement and three had improved erectile dysfunction postoperatively.Two subjects had wound dehiscence, both of which were managed conservatively (Clavien I).Median elastin fiber:collagen fiber ratio was 5, with a range of 5-20.Most subjects' plaques were comprised of 90% or greater collagen and 5% or less of elastin (Figure 1A).One subject's plaque was comprised of 15% elastin fibers (Figure 1B).This individual had a calcified plaque with a 65-degree curvature and had intact erectile function and was the only subject included in this study who had not had any Peyronie's therapy prior to his plaque excision and grafting.For this individual, it is unclear whether his Peyronie's disease is less severe or whether some standard Peyronie's disease treatments alter elastin.Conclusions: Following plaque excision and grafting, subjects had improved curvature and erectile dysfunction with few complications.Plaques were primarily composed of collagen with minimal elastin.Less severe disease may be associated with greater elastin content.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.286 | 0.078 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".