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Record W4387358716 · doi:10.1016/j.focha.2023.100476

Understanding the emerging potential of synthetic biology for food science: Achievements, applications and safety considerations

2023· article· en· W4387358716 on OpenAlexafffund
Ramila Cristiane Rodrigues, Higor Sette Pereira, Renato Lima Senra, Andréa de Oliveira Barros Ribon, Tiago Antônio de Oliveira Mendes

Bibliographic record

VenueFood Chemistry Advances · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCRISPR and Genetic Engineering
Canadian institutionsUniversity of Lethbridge
FundersConsórcio Pesquisa CaféConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorCanada Research ChairsFundação de Amparo à Pesquisa do Estado de Minas GeraisNatural Sciences and Engineering Research Council of CanadaBill and Melinda Gates Foundation
KeywordsSynthetic biologyBiosecurityBiosafetyToolboxBiotechnologyRisk analysis (engineering)Engineering ethicsBiochemical engineeringNanotechnologyComputer scienceBusinessBiologyEngineeringComputational biologyEcology

Abstract

fetched live from OpenAlex

The advent of the first synthetic cell has triggered significant interest in synthetic biology research and its potential impact on various fields, including industry, agriculture, health, and the environment. With its unique blend of molecular biology, genetics, engineering, and computational modelling, synthetic biology is becoming a crucial tool in addressing challenges in food science. For example, the development of synthetic genetic circuits is underway for the improvement of food safety and quality, such as creating biosensors for detecting toxins and heavy metals, enhancing the nutritional value of foods, and preserving the environment using sustainable technologies. Regardless of its potential, the use of synthetic biology in food production raises concerns regarding biosafety, asking for stringent control and comprehensive legislation to prevent misuse of the technology. This review provides an overview of synthetic biology in food science, discussing the current state-of-art of its toolbox achievements for cost-effective and nutritional improvement, likewise, the legal, ethical, and biosecurity considerations surrounding the use of synthetic circuits for the advancement of food science.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.584
Threshold uncertainty score0.280

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.313
Teacher spread0.291 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2023
Admission routes2
Has abstractyes

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