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Record W4387581783 · doi:10.19083/tesis/667204

Prognostic impact of neutrophil-to-lymphocyte ratio in traumatic brain Injury: A systematic review and meta-analysis

2022· review· es· W4387581783 on OpenAlexaboutno aff
Maziel Andrea Garagatti Montero, Esteban Alonso Alarcon Braga

Bibliographic record

VenueUniversidad Peruana de Ciencias Aplicadas (UPC) · 2022
Typereview
Languagees
FieldMedicine
TopicTraumatic Brain Injury and Neurovascular Disturbances
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineGynecologyInternal medicine

Abstract

fetched live from OpenAlex

Disponer de herramientas para evaluar el pronóstico en pacientes con traumatismo craneoencefálico (TEC) es fundamental para un manejo terapéutico individualizado. La proporción de neutrófilos a linfocitos (NLR) es un biomarcador inflamatorio ampliamente utilizado que ha demostrado tener una capacidad pronóstica en varias enfermedades neurológicas, incluido el TEC. Sin embargo, no existe una revisión sistemática que resuma la evidencia disponible. Realizamos una búsqueda bibliográfica en 6 bases de datos. La calidad de los estudios se evaluó mediante la Newcastle-Ottawa Scale (NOS). Las medidas de efecto se expresaron como odds ratios (OR) y sus intervalos de confianza (IC) al 95%. Las diferencias de medias estandarizadas se convirtieron a Log[OR] utilizando el método de Chinn. El análisis cuantitativo se realizó mediante un modelo de efectos aleatorios. El efecto de los estudios pequeños se evaluaron con la prueba de Egger. Se incluyeron 8 estudios de cohortes. Los resultados no mostraron asociación entre los valores de NLR y la mortalidad en pacientes con diagnóstico de TEC (OR 2,42;IC95% 0,63-9,28; p=0,20; I2=92 %) o con resultados favorables/desfavorables en pacientes con TEC (OR 3,00,95 % IC 0,76-11,85, p=0,12,I2=99%). Los análisis de subgrupos no mostraron asociación (Resultado temprano: OR 2,63,IC95%:0,99-6,96; p=0,05;I2=95 %) (Resultado tardío: OR 3,36, IC95 %:0,22-52,17;p=0,39;I2=100 %). No hubo indicios de efecto de estudios pequeños para el resultado favorable/desfavorable (prueba-de-Egger=0,149). No encontramos asociación entre los valores de NLR y el resultado favorable/desfavorable o la mortalidad. Se requieren más estudios de alta calidad para tener una mejor perspectiva de las capacidades pronósticas de NLR en TEC.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.010
metaresearch head score (Gemma)0.024
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.015
Threshold uncertainty score0.053

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0100.024
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0150.027
Bibliometrics0.0080.009
Science and technology studies0.0010.001
Scholarly communication0.0030.002
Open science0.0020.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.069
GPT teacher head0.344
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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