S3272 Something's Stuck: An Atypical Presentation of Crohn’s Disease
Bibliographic record
Abstract
Introduction: Crohn’s disease (CD) is a gastrointestinal (GI) disorder normally categorized by discontinuous chronic inflammation with focal crypt architectural distortion and granuloma formation occurring anywhere along the GI tract. Clinically significant isolated upper GI disease occurs in only 0.5-4% of all patients with CD. We describe the case of a middle-aged man with recurrent esophageal and duodenal stenosis presumably secondary to limited CD of the upper GI tract. Case Description/Methods: This is a 47-year-old man with an ongoing history of GERD, dysphagia, and post-prandial abdominal pain dating back to 2016. Labs were notable for low vitamin D, normal inflammatory markers, and a positive scl70 antibody. Other laboratory work-up was unremarkable with negative H. pylori, syphilis, HIV, QuantiFERON gold, and CMV. He has undergone multiple upper endoscopies that have demonstrated severe gastritis and duodenitis with esophageal and duodenal strictures requiring dilation. Biopsy results were initially unclear but have since shown active gastritis and duodenitis with cryptitis, crypt abscesses, surface erosions, and increased lymphoplasmacytic inflammatory cells within the lamina propria and muscularis mucosa. Calcium phosphate crystals with giant cell reactions were seen on gastric biopsy during one endoscopy. Esophageal biopsies have shown increased intra-epithelial lymphocytes at the areas of stricture as well as in the distal and proximal esophagus. A colonoscopy was endoscopically normal, and biopsies were normal from terminal ileum, right and left colon, and rectum. Symptoms have improved with previous trials of steroids. A multi-disciplinary conference was held given the chronicity and complexity of his case. There is concern for scleroderma overlap given positive scl70 antibody and calcifications on gastric biopsy, however, the consensus suspicion is of limited CD of the upper GI tract. The decision was made to pursue empiric treatment of his presumed limited CD with anti-TNF alpha biologic therapy (Figure 1). Discussion: The Vienna and Montreal classifications are commonly utilized tools to categorize the phenotypical presentations of CD with L4 disease (isolated upper GI tract) being any involvement of the GI tract proximal to the terminal ileum; more specific varieties such as L4-esophagogastruduodenal disease have also been described. This case demonstrates a rare version of limited CD of the upper GI tract and highlights the importance of a multi-disciplinary approach to treatment.Figure 1.: Top: Stenosis of upper esophagus; Upper left: Chronic active gastritis; Upper right: Chronic active gastritis with neutrophils in lamina propria; Lower left: Duodenal bulb stenosis; Lower right: Chronic active duodenitis with neutrophilic and eosinophilic infiltrate in the lamina propria with crypt distortion.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".